2,4,6-tribromophenol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

not specified

Test type:

traditional method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,4,6-tribromophenol

EC Number:

204-278-6

EC Name:

2,4,6-tribromophenol

Cas Number:

118-79-6

Molecular formula:

C6H3Br3O

IUPAC Name:

2,4,6-tribromophenol

Test material form:

solid: granular

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Lot No. 812-141

Test animals

Species:

rat

Strain:

other: Spartan albino rats

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

whole body

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: dynamic air flow chamber
- Exposure chamber volume:
- Method of holding animals in test chamber:
- Source and rate of air:
- Method of conditioning air:
- System of generating particulates/aerosols:
- Method of particle size determination:
- Treatment of exhaust air:
- Temperature, humidity, pressure in air chamber:

TEST ATMOSPHERE
- Brief description of analytical method used:
- Samples taken from breathing zone: yes/no

VEHICLE
- Composition of vehicle (if applicable):
- Concentration of test material in vehicle (if applicable):
- Justification of choice of vehicle:
- Lot/batch no. (if required):
- Purity:

TEST ATMOSPHERE (if not tabulated)
- Particle size distribution:
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.):

CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration:

Duration of exposure:

4 h

Concentrations:

50 mg/l

No. of animals per sex per dose:

5

Details on study design:

Acute toxicity was evaluated in Spartan albino rats (5 rats/sex), receiving whole-body exposure to micronized tribromophenol at a concentration of 50 mg/l, for 4 hours, in a dynamic air flow chamber.

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 50 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Mortality:

The treatment had no adverse effects with respect to mortality rate.

Clinical signs:

other: During the exposure period, rats exhibited decreased motor activity, eye squint, slight dyspnea, erythema and ocular porphyrin discharge. At 24 hrs, rats exhibited diarrhea, ocularporphyrin discharge, and slight dyspnea. During the 14-day observation peri

Body weight:

The treatment had no adverse effects with respect to body weight gain.

Gross pathology:

A necropsy of all rats following the 14 day observation period did notreveal any compound related findings.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In accordance with the results obtained, the acute inhalation toxicity of TBP would be greater than 50 mg/L.