Registration Dossier
Registration Dossier
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EC number: 204-118-5 | CAS number: 115-96-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited study details, but recognised guideline followed. Study referenced in EU Risk Assessment Report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- The skin of 3 albino rabbits was semi-occlusively exposed to 0.5 mL of undiluted test material (purity > 99%) per animal for 4 hours.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tris (2-Chloroethyl) Phosphate
- IUPAC Name:
- Tris (2-Chloroethyl) Phosphate
- Details on test material:
- Not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- Not specified
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- Three
- Details on study design:
- As guideline
Results and discussion
In vivo
- Irritant / corrosive response data:
- All animals showed slight erythema that reversed within 24 hours.
Any other information on results incl. tables
No further data available.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
