Registration Dossier
Registration Dossier
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EC number: 200-813-2 | CAS number: 74-83-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Guideline:
- other: As this is an academic piece of work, no specific guidelines were required.
- GLP compliance:
- no
- Remarks:
- No, the study is an academic piece of work for which GLP was not required.
Test material
- Reference substance name:
- Bromomethane
- EC Number:
- 200-813-2
- EC Name:
- Bromomethane
- Cas Number:
- 74-83-9
- Molecular formula:
- CH3Br
- IUPAC Name:
- bromomethane
- Details on test material:
- Test material: Methyl Bromide: batch no.: not specified; purity 99.9%
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Details on dermal exposure:
- Six groups of nine rats were injected Methyl Bromide-liquid paraffin by sc injection at doses of 75, 100, 125, 150, 200 and 250 mg/kg bw. Mortality was observed for one week after injection, and the LD50 was determined.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 135 mg/kg bw
- Mortality:
- The LD50 of Methyl Bromide was found to be 135mg/kg in the rat. The 100% survival and 100% lethal doses were 75mg/kg and 250mg/kg, respectively. A total of 28 rats died: 27 within 24 h and one on day 4 after Methyl Bromide administration.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
