Registration Dossier
Registration Dossier
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EC number: 274-764-0 | CAS number: 70693-32-2
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility for Daphnia magna (OECD 202 Part 2); read-across
Key value for chemical safety assessment
Additional information
No studies are available on the toxicity of Decanoic acid, mixed esters with neopentyl glycol and octanoic acid (CAS No. 70693-32-2) to aquatic invertebrates. Therefore, a read-across to the structurally similar category members Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5), 2,2-dimethyl-1,3-propanediyl dioleate (CAS No. 42222-50-4) and Decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate (CAS No. 11138-60-6) was conducted. This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification in Section 13.
The key study conducted with Decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate (CAS No. 11138-60-6) was performed according to OECD Guideline 202 Part 2, in a static system (Low, 1996). The test organism Daphnia magna was exposed to the test substance at the nominal test concentrations of 24, 97, 242, 1018 and 2570 mg/L for 15 days. On day 15, it was observed that at least 80% of the surviving control females dropped their third brood, and the test was terminated. The test solutions were prepared as water accommodated fractions (WAF). No significant immobilisation was observed during the study, and the NOELR was reported to be 2570 mg/L.
The study conducted with 2,2-dimethyl-1,3-propanediyl dioleate (CAS No. 42222-50-4) was performed as a limit test according to OECD guideline 211 and GLP (Schlechtriem, 2013). The test organism Daphnia magna was exposed to the test substance in a semi-static system for 21 days, at a loading rate of 1 mg/L (WAF). No significant effect on reproduction was observed during the study, and the NOELR was determined to be ≥ 1 mg/L.
The key study conducted with Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5) was performed according to OECD Guideline 211 and GLP, in a semi-static system (Parr, 2013). During 21 days, the test organism Daphnia magna was exposed to five test concentrations up to 0.0019 mg/L (measured, TWA). No significant effects on reproduction were observed during the study and the NOEC (21d) was reported to be ≥ 0.0019 mg/L.
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