Registration Dossier
Registration Dossier
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EC number: 256-360-6 | CAS number: 48145-04-6
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
A study was performed to determine the rate of hydrolysis of MIRAMER M140 as a function of pH. The test was conducted in accordance with the preliminary test as described in Commission Regulation (EC) No. 440/2008 (Method C.7) and the OECD Guidelines for Testing of Chemicals (Method 111).. The study was conducted in compliance with GLP.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
A preliminary study showed that at pH 4 and 50 +/- 0.5ºC, less than 10% hydrolysis had occurred after 5 days, equivalent to a half-life of greater than 1 year under environmental conditions (25°C).
At each of pH 7 and 9 and 50 +/- 0.5ºC, more than 10% hydrolysis had occurred after 5 days, equivalent to a half-life of less than 1 year under environmental conditions (25°C).
MIRAMER M140 was determined to be hydrolytically stable under acidic conditions, but unstable under neutral and basic conditions.
Estimation by SPARC using SMILES notation for the substance gave a hydrolytic half-life =150 d at pH=7, which is
is in compliance with screening study (hydrolytic half-life < 1 year at pH=7).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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