Registration Dossier
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EC number: 215-553-5 | CAS number: 1330-86-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility (< 0.05 mg/L in aqua dest) for algae
Key value for chemical safety assessment
Additional information
No studies investigating the toxicity of Diisooctyl adipate (CAS 1330-86-5) to algae are available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category members Bis(2-ethylhexyl)adipate (CAS 103-23-1) and Diisononyl adipate (CAS 33703-08-1) was conducted. Further justification is given within the endpoint summary 6.1 and within the category justification section 13.In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used.
The test with Bis(2-ethylhexyl)adipate (CAS 103-23-1) was conducted according to OECD 201 using Pseudokirchneriella subcapita as test organism (MOE, 2000). A mixture of DMF and HCO-40 was used as vehicle at a concentration of 100 mg/L. Only one test concentration was applied (50 mg/L nominal, 46 mg/L measured).No adverse effects were observed. Therefore, the EC50 (72h) is assessed as > 50 mg/L (nominal) and > 46 mg/L (measured).
The test with Diisononyl adipate (CAS 33703-08-1) was conducted under static conditions similar to OECD 211 using Desmodesmus subspicatus as test organism (BASF, 1990).Cremophor RH 40 was used as vehicle at a concentration of 100 mg/L. Test concentrations of 0.78, 1.56, 3.13, 6.25, 12.5, 25, 50, 100 mg/L were applied.The EC50/EC10 (72h) was calculated as > 100/72 mg/L (nominal), based on growth rate.
Due to structural and property similarities to the analogue substances Diisononyl adipate (CAS 33703-08-1) and Bis(2-ethylhexyl)adipate (CAS 103-23-1) these results are also applicable to read across to Diisooctyl adipate (CAS 1330-86-5).
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