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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2002
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available

Data source

Reference
Reference Type:
publication
Title:
Gas Chromatography: An Investigative Tool in Multiple Allergies to Essential Oils.
Author:
Dharmagunawardena B, Takwale A, Sanders KJ, Cannan S, Rodger A and Ilchyshyn A
Year:
2002
Bibliographic source:
Contact Dermatitis. 47(5): 288-292

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Principles of method if other than guideline:
Method: Single Patch test performed in a patient
GLP compliance:
not specified

Test material

1
Reference substance name:
Rosemary, ext.
EC Number:
283-291-9
EC Name:
Rosemary, ext.
Cas Number:
84604-14-8
Molecular formula:
Not applicable for UVCB substance
IUPAC Name:
Essential oil of Rosmarinus officinalis L. (Lamiaceae) obtained from leaves, flowers and twigs by steam distillation
Test material form:
liquid

Method

Type of population:
other: clinical case presented with suspected allergic contact dermatitis
Controls:
No
Route of administration:
dermal

Results and discussion

Results of examinations:
- Rosemary oil showed a positive reaction (oedematous/vesicular reaction) on Day 4.
- It was found to be composed of terpineol (> 1 %), and α-pinene, linalool, and caryophylene (>10 %).

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:
Rosemary oil showed a positive reaction (oedematous/vesicular reaction) on Day 4. It was found to be composed of terpineol (>1 %), and α-pinene, linalool, and caryophylene (>10 %).
Executive summary:

In a skin sensitisation study, a female patient (51 year old professional aromatherapist presented with suspected allergic contact dermatitis) was applied with occlusive patches containing rosemary oil diluted in white petrolatum, for 48 h. The reactions were observed at 30 min. after removal of patches and on Day 4. The composition of the oil was analysed using GC-MS chromatography.

Rosemary oil showed a positive reaction (oedematous/vesicular reaction) on Day 4. It was found to be composed of terpineol (>1 %), and α-pinene, linalool, and caryophylene (>10 %).