Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V, B6
GLP compliance:
yes
Type of study:
guinea pig maximisation test

Test material

Constituent 1
Chemical structure
Reference substance name:
3,5-dichloro-2,4-difluorobenzoyl fluoride
EC Number:
401-800-6
EC Name:
3,5-dichloro-2,4-difluorobenzoyl fluoride
Cas Number:
101513-70-6
Molecular formula:
C7HCl2F3O
IUPAC Name:
3,5-dichloro-2,4-difluorobenzoyl fluoride

In vivo test system

Test animals

Species:
guinea pig
Strain:
Dunkin-Hartley
Sex:
male/female

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
other: First challenge
Hours after challenge:
24
Group:
test chemical
No. with + reactions:
15
Total no. in group:
20
Remarks on result:
other: Reading: other: First challenge. . Hours after challenge: 24.0. Group: test group. No with. + reactions: 15.0. Total no. in groups: 20.0.
Reading:
other: First challenge
Hours after challenge:
48
Group:
test chemical
No. with + reactions:
13
Total no. in group:
20
Remarks on result:
other: Reading: other: First challenge. . Hours after challenge: 48.0. Group: test group. No with. + reactions: 13.0. Total no. in groups: 20.0.
Reading:
other: Second challenge
Hours after challenge:
24
Group:
test chemical
No. with + reactions:
20
Total no. in group:
20
Remarks on result:
other: Reading: other: Second challenge. . Hours after challenge: 24.0. Group: test group. No with. + reactions: 20.0. Total no. in groups: 20.0.
Reading:
other: Second challenge
Hours after challenge:
48
Group:
test chemical
No. with + reactions:
18
Total no. in group:
20
Remarks on result:
other: Reading: other: Second challenge. . Hours after challenge: 48.0. Group: test group. No with. + reactions: 18.0. Total no. in groups: 20.0.
Reading:
other: First challenge
Hours after challenge:
24
Group:
negative control
No. with + reactions:
0
Total no. in group:
20
Remarks on result:
other: Reading: other: First challenge. . Hours after challenge: 24.0. Group: negative control. No with. + reactions: 0.0. Total no. in groups: 20.0.
Reading:
other: First challenge
Hours after challenge:
48
Group:
negative control
No. with + reactions:
0
Total no. in group:
20
Remarks on result:
other: Reading: other: First challenge. . Hours after challenge: 48.0. Group: negative control. No with. + reactions: 0.0. Total no. in groups: 20.0.
Reading:
other: Second challenge
Hours after challenge:
24
Group:
negative control
No. with + reactions:
0
Total no. in group:
20
Remarks on result:
other: Reading: other: Second challenge. . Hours after challenge: 24.0. Group: negative control. No with. + reactions: 0.0. Total no. in groups: 20.0.
Reading:
other: Second challenge
Hours after challenge:
48
Group:
negative control
No. with + reactions:
0
Total no. in group:
20
Remarks on result:
other: Reading: other: Second challenge. . Hours after challenge: 48.0. Group: negative control. No with. + reactions: 0.0. Total no. in groups: 20.0.

Applicant's summary and conclusion