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EC number: 213-926-7 | CAS number: 1067-25-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-08-31 to 1994-11-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-A (Determination of the "Ready" Biodegradability - Dissolved Organic Carbon (DOC) Die-Away Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of activated sludge: Marl-Ost municipal sewage treatment plant, The sewage sludge was sampled on 1994-09-07.
- Storage conditions: The determination of suspended solids was carried out before the inoculum. During this time the sludge had to be aerated by aerating tube.
- Preparation of inoculum for exposure: The sludge was centrifuged for 15 min at 3000 rpm. The supernatant was then discarded and the sludge resuspended in mineral medium (washing step). After repeated centrifugation, the sludge was resuspended.
- Concentration of sludge: 3.45 g/L dry matter
- Initial cell/biomass concentration: Inoculum was added to the test batches at a dry matter of content 27.6 mg/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 13.33 mg/L
- Based on:
- DOC
- Remarks:
- after 3 h in test batch
- Initial conc.:
- 11.28 mg/L
- Based on:
- DOC
- Remarks:
- after 3 h in control batch
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- Vessels: 2000 ml conial flasks with loose aluminium foil closure
Test batches:
2 flasks containing test substance (11.2 mg DOC/l after 3h) and inoculum
2 flasks without test substance, but with inoculum (= blank batch)
2 flasks containing control subsatnce (sodium benzoate: 10.8 mg DOC/l after 3 hours) and inoculum
Method:
Addition of inoculum corresponding a dry matter content of 27.6 mg/test medium.
Filling up with about 2 l mineral medium
30 ml/l test substance stock solution, respectively 20 ml/l control substance stock solution, were given into the test vessels from which the test and control substance batches were filled up.
The content of substances was in mean value 13.33 mg DOC/l (after 3h) in the test batches, respectively 11.28 mg DOC/l (after 3 h) in the control batches.
The batches were filled up to 2.5 l with mineral medium.
From this batches two times 1000 ml were given into 2000 ml Erlenmeyer flasks.
The loosely covered flasks were incubated at 21.9 to 22.2 °C in the dark on a mechanical shaker for 28 days. - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- 50
- Sampling time:
- 7 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 55
- Sampling time:
- 14 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 54
- Sampling time:
- 21 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 55
- Sampling time:
- 27 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 54
- Sampling time:
- 28 d
- Details on results:
- Results with reference substance:
98% DOC decrease after 7 days
99% DOC decrease after 14 days
100% DOC decrease after 21 days
99% DOC decrease after 27 days
99% DOC decrease after 28 days - Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- A biodegradation result of 54% in 28 days was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Reference
DOC measurements of the test item
|
DOC concentration after n days (mg/l) |
||||||||
|
Flask no. |
|
O h (C0) |
3h (C3) |
7 |
14 |
21 |
27 |
28 |
Test batches (Mineral medium + test item + inoculum) |
1 |
a1 |
13.58 |
13.59 |
7.53 |
6.16 |
6.43 |
6.78 |
6.83 |
a2 |
13.32 |
14.13 |
7.41 |
6.31 |
6.43 |
7.02 |
6.74 |
||
Ca (t) = (a1 + a2) /2 |
13.45 |
13.86 |
7.47 |
6.24 |
6.43 |
6.90 |
6.79 |
||
2 |
b1 |
12.25 |
13.78 |
7.04 |
6.74 |
6.62 |
6.28 |
6.61 |
|
b2 |
12.30 |
13.38 |
7.00 |
6.77 |
6.67 |
6.37 |
6.80 |
||
Cb (t) = (b1+ b2) /2 |
12.28 |
13.58 |
7.02 |
6.76 |
6.65 |
6.33 |
6.71 |
||
Blank batches (Mineral medium + inoculum) |
1 |
c1 |
0.52 |
0.36 |
0.61 |
0.50 |
0.43 |
0.60 |
0.62 |
c2 |
0.56 |
0.39 |
0.54 |
0.44 |
0.42 |
0.65 |
0.62 |
||
Cc (t) = (c1 + c2) /2 |
0.54 |
0.38 |
0.58 |
0.47 |
0.43 |
0.63 |
0.62 |
||
2 |
d1 |
0.49 |
0.36 |
0.70 |
0.53 |
0.49 |
0.60 |
0,62 |
|
d2 |
0.44 |
0.41 |
0.68 |
0.49 |
0.49 |
0.61 |
0.59 |
||
Cd (t) 0 (d1 + d2) /2 |
0.47 |
0.39 |
0.69 |
0.51 |
0.49 |
0.61 |
0.61 |
||
|
Cbl(t)=Cc(t)+Cd(t)/2 |
0.51 |
0.39 |
0.64 |
0.49 |
0.46 |
0.62 |
0.62 |
Description of key information
54% in 28 days (EU Method C.4-A)
Key value for chemical safety assessment
Additional information
Trimethoxypropylsilane hydrolyses rapidly to propylsilantriol and methanol. The degradation observed in the biodegradation test is likely to be due to the degradation of methanol, which is expected to biodegrade rapidly and makes up 3 out of the 6 carbons in the molecule. Propylsilanetriol is not expected to biodegrade to any significant extent. A biodegradation result of 54% in 28 days was determined in a reliable study conducted according to EU method C.4 -A and in compliance with GLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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