Registration Dossier
Registration Dossier
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EC number: 217-752-2 | CAS number: 1948-33-0
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/sediments:
The bioaccumulation study in aquatic organisms was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a log Kow of 2.94 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 24 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-bioaccumulative in aquatic organisms.
Additional information
Bioaccumulation: aquatic/sediments:
Experimental studies for test chemical and its structurally similar read across chemical have been reviewed for bioaccumulation endpoint and their results are summarized below.
First study was reveiwed from authoritative database ( HSDB, 2017) in this study the the bioaccumulation factor (BCF) value was calculated using a log Kow of 2.94 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 24 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-bioaccumulative in aquatic organisms.
Another study was reviewed from authoritative database (J check) in this study the Bioaccumulation test was conducted for 6 weeks for determination the bioconcentration factor (BCF) of test chemical on test organism Cyprinus carpio. Recovery ratio : Test water : 1st concentration area : 90.1 %, 2nd concentration area : 79.6 %, Fish : 92.7 %, - Limit of detection : Fish : 0.
ppm And Nominal concentrations used in the study as - 1st Concentration area: 0.0001 mg/L, 2nd Concentration area : 0.00001 mg/L and Range finding study was carried out on Rice fish (Oryzias latipes) TLm(48h) 6.4 ppm(w/v), Rice fish (Oryzias latipes).Thus according to static Fish test the bioconcentration factor (BCF) for test chemical was determined according static fish test. The BCF value was observed to be 16-21 L/kg at dose concentration 0.0001 mg/L and 8.1-18 L/kg at dose concentration 0.00001 mg/L on test organism Cyprinus carpio during 6 weeks period.Therefore it is concluded that this test chemical is nonbioaccumulative.
In last study the BCF value of test chemical was estimated is 57 dimensionless by using log Kow of 3.50 and regression derived equation and it is far less than 2000 so it is concluded that this chemical is non bioaccumulative.
By considering results of all the studies mentioned above it can be concluded that test chemical is non-bioaccumulative in nature.
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