Calcium dipropionate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Documentation is poor, however, the result is consitent with the result of the key study.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Range finding toxicity data: list Vi

Author:

Smyth, H.F. jr., Carpenter C.P., Weil C.S., Pozzani U.C., Striegel J.A.

Year:

1962

Bibliographic source:

Am. Ind. Hyg. Assoc. J. 23, 95-107 (1962)

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

no

Remarks:

Inhalation hazard test as in the Annex

Principles of method if other than guideline:

inhalation hazard test

GLP compliance:

no

Test type:

other: inhalation hazard test

Test material

Test material information

Constituent 1

Reference substance name:

Propionic acid

EC Number:

201-176-3

EC Name:

Propionic acid

Cas Number:

79-09-4

Molecular formula:

C3H6O2

IUPAC Name:

propionic acid

Details on test material:

- Name of test material: propionic acid
Analytical purity: no data

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

6 albino rats per sex were put into a 120 l exposure chamber for an 8 h exposure towards a propionic acid vapor atmosphere. The test atmosphere was generated by passing 2.5 liters of air / minute through a fritted glass disk into a 50 ml gas wash bottle containing propionic acid. Vapor concentration is generated with different flowing streams of vapor by proportioning pumps. Concentrations are nominal concentrations.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

vapour saturated atmosphere (nominal concentration 12.2 mg/l)

No. of animals per sex per dose:

6 animals

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: only mortality recorded

Statistics:

not necessary

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LC0

Effect level:

12.2 other: mg/l

Exp. duration:

8 h

Remarks on result:

other: No mortality after 8 h exposure to an atmosphere enriched or saturated at 20°C

Effect levels 2

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 20 mg/L air (nominal)

Exp. duration:

4 h

Mortality:

No mortality after 8 h exposure to an atmosphere enriched or saturated at 20°C.
this is equivalent to a LC0 of 24.4 mg/L/4h according to the Haber rule

Clinical signs:

other: not reported

Body weight:

not reported