Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 265-228-7 | CAS number: 64755-01-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: GLP-status not known, guideline not known, information from a peer-reviewed, published review article. Notable limitations in design and/or reporting, reliability not known.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Reference Type:
- publication
- Title:
- The penetration of the human skin by fatty alcohol sulfates and sodium soaps of fatty acids (C8-C18) and its relation to causes of irritation
- Author:
- Szakall A, Schulz KH
- Year:
- 1 960
- Bibliographic source:
- Fette Seifen Anstrichm., vol. 62, pp. 170-175 cited in CIR (1982)
Materials and methods
- Principles of method if other than guideline:
- - Method: Humans were exposed to 0.5 % sodium stearate in aqueous solution and the rate of penetration through skin was assessed.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium stearate
- EC Number:
- 212-490-5
- EC Name:
- Sodium stearate
- Cas Number:
- 822-16-2
- IUPAC Name:
- sodium stearate
- Test material form:
- other: Aqueous solution
- Details on test material:
- No data reported
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data reported
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Duration of exposure:
- No data reported
- Doses:
- - Concentration: 0.5 % sodium stearate in aqueous solution
- No. of animals per group:
- No data reported
- Details on study design:
- No data reported
- Details on in vitro test system (if applicable):
- No data reported
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
- Absorption in different matrices:
- - Rate of penetration: 0.1 mg/ 100 mL/ minute through human skin
- Total recovery:
- No data reported
- Conversion factor human vs. animal skin:
- Not applicable
Applicant's summary and conclusion
- Conclusions:
- The rate of penetration of 0.5 % sodium stearate in aqueous solution through human skin was determined to be 0.1 mg/ 100 mL/ minute.
- Executive summary:
The rate of penetration of 0.5 % sodium stearate in aqueous solution through human skin was determined to be 0.1 mg/ 100 mL/ minute. No information on the test methods used is available in the publication (CIR 1982). However, this information is taken from a peer reviewed article and can be considered adequate for use for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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