Registration Dossier
Registration Dossier
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EC number: 403-360-0 | CAS number: 42405-40-3 BONTRON E-84; E-84
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline and GLP compliant study
Data source
Reference
- Reference Type:
- other: Inquiry result from ECHA
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline No. 471
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
- EC Number:
- 403-360-0
- EC Name:
- Bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
- Cas Number:
- 42405-40-3
- Molecular formula:
- C30H42O6Zn
- IUPAC Name:
- bis(3,5-bis(1,1-dimethylethyl)-2-hydroxybenzoato-O1,O2)zinc
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: S. typhimurium strains TA100, TA98, TA1535, TA 1537
- Metabolic activation system:
- Aroclor 1254 induced rat liver S9-homogenate
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 15 ...1500ug/plate
Concentration range in the main test (without metabolic activation): 15 ...1500ug/plate - Vehicle / solvent:
- Solvent: DMSO
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: S. typhimurium strains TA100, TA98, TA1535, TA 1537
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (5000ug/plate)
- Species / strain:
- bacteria, other: S. typhimurium strains TA100, TA98, TA1535, TA 1537
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (5000ug/plate)
- Species / strain:
- bacteria, other: S. typhimurium strains TA100, TA98, TA1535, TA 1537
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (>1500ug/plate)
- Species / strain:
- bacteria, other: S. typhimurium strains TA100, TA98, TA1535, TA 1537
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (>1500ug/plate)
- Additional information on results:
- No substantial increases in revertant colony numbers of any of the 4 tester strains were observed.
- Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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