L-Leucine, 4-fluoro-N-[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]-, compd. with N-cyclohexylcyclohexanamine (1:1)

Flammability

Administrative data

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

December 16, 2011 - January 27, 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: This study has been performed according to UN and EU guidelines and in compliance with GLP principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Version / remarks:

(O.J. no. L142, 2008)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: UN no. ST/SG/AC.10/11/Rev.5: RTDG, Part III, Test N.1: “Test Method for Readily Combustible Solids”, 2009

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

N-cyclohexylcyclohexanaminium (2S)-4-fluoro-4-methyl-2-{[(1S)-2,2,2-trifluoro-1-{4'-methanesulfonyl-[1,1'-biphenyl]-4-yl}ethyl]amino}pentanoate

EC Number:

700-778-8

Cas Number:

1064076-86-3

Molecular formula:

C21H23F4NO4S.C12H23N

IUPAC Name:

N-cyclohexylcyclohexanaminium (2S)-4-fluoro-4-methyl-2-{[(1S)-2,2,2-trifluoro-1-{4'-methanesulfonyl-[1,1'-biphenyl]-4-yl}ethyl]amino}pentanoate

Details on test material:

- Name of test material (as cited in study report): Biphenyl DCHA Salt
- Description: White powder

Results and discussion

Flammable solids

Test procedure:

burning time (test type not further specified)

Remarks:

or specified in description of method (migrated information)

Burning time:

36 s

Remarks on result:

other: highest time of 6 tests

Any other information on results incl. tables

Preliminary screening test

The flame of a gas burner did ignite the test substance pile. The test substance melted and burned with a yellow/blue flame and turned into a brown/yellow residue. White smoke was observed. The burning time over a distance of 200 mm, after the pile had burned a distance of 50 mm, was 50 seconds. According to this, the burning rate test was performed.

Burning rate test

The burning times over 100 mm, after the pile had burned a distance of 80 mm, are shown in the table below. All burning times are less than 45 seconds. According to this, the test substance is considered ‘highly flammable’.

Test	Burning time over 100 mm (s)^#
1	28
2	22
3	22
4	36
5	24
6	22

^#Time measured after the pile had burned over 80 mm.

 

Propagation of combustion was stopped by the wetted zone. The flame extinguished 30-40 seconds after reaching the wetted zone. It was therefore concluded that the wetted zone stopped the flame for at least 4 minutes in all 6 tests.

Applicant's summary and conclusion

Interpretation of results:

highly flammable

Remarks:

Migrated information

Conclusions:

Biphenyl DCHA Salt burned with a yellow/blue flame and the time of burning was less than 45 seconds. According to this, the test substance is considered ‘highly flammable’. The wetted zone applied in the burning rate test stopped the flame for at least 4 minutes.