Registration Dossier
Registration Dossier
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EC number: 610-992-2 | CAS number: 53378-52-2
Endpoint summary
Administrative data
Description of key information
Short term toxicity to fish
In two independent 96-h acute toxicity studies, bluegills (Lepomis macrochirus) andrainbow trout (Oncorhynchus mykiss)were exposed to CT 473 -91 at nominal concentrations of 0 (water control), 5.6, 10, 18, 32 and 56 mg/L under static conditions.
The NOEC value was 18 mg/L for both studies. The LC50values were 42 and 30 mg/L (as nominal concentrations) for blue gills and rainbow trout, respectively.Both toxicity studies are classified as reliable without restrictions since they satisfy the guideline requirements for the fish acute toxicity study (OECD 203). However, water concentrations of test compound were not measured in either of the studies.
Based on a conservative approach, the study conducted with rainbow trout was choosen as the“key study” since it has the lowest LD50value.
Short term toxicity to aquatic invertebrates
In the first 48-h acute toxicity study, water fleas (Daphnia magna) were exposed to CT 473 -91 at nominal concentrations of 0 (water control), 32, 56, 100, 180 and 320 mg/L under static conditions.The NOEC value was 32 mg/L and the LC50was 42 mg/L (as nominal concentrations).
In the second 48-h acute toxicity study, water fleas (Daphnia magna) were exposed toS-10783at the followingnominal concentrations: control, 10, 22, 46, 100, 220 mg/L.The NOEC was 10 mg/L and the EC50 was 53 mg/L(as nominal concentrations).
Both toxicity studies are classified as reliable without restrictions since it satisfies the guideline requirements for the Daphnia acute toxicity study (OECD 202). However, water concentrations were only confirmed analytically in the second study. Consequently, the second study was selected as the “key study”.
Toxicity to aquatic algae and cyanobacteria
Green algae (Pseudokirchneriella subcapitata) were exposed to S-10783 at the following nominal concentrations: Control, 0.10, 1, 10, 100 mg/L. The NOEC and EC50 for both growth rate and biomass were >= 100 mg/L (as nominal concentrations).
Additional information
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