Registration Dossier
Registration Dossier
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EC number: 630-348-4 | CAS number: 84268-36-0
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Remarks:
- other: short-term and subchronic exposure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- 3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoic acid
- EC Number:
- 630-348-4
- Cas Number:
- 84268-36-0
- Molecular formula:
- C19H21N3O3
- IUPAC Name:
- 3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino RAI
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 5 male rats
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
- Method of administration:
Gavage - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- 0, 10, 50, 200 mg/ml
- Duration of treatment / exposure:
- Test duration: 14 days
- Frequency of treatment:
- Once daily for consecutive 14 days period.
- No. of animals per sex per dose:
- Male: 5 animals at 0 mg/kg bw/day
Male: 5 animals at 10 mg/kg bw/day
Male: 5 animals at 50 mg/kg bw/day
Male: 5 animals at 200 mg/kg bw/day
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- > 200 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No toxicity was observed during treatment. NOAEL is >200 mg/kg.
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