Registration Dossier
Registration Dossier
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EC number: 616-053-3 | CAS number: 74149-73-8
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted under GLP conditions according to OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-methoxy-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-2-nitrophenyl]benzamide
- EC Number:
- 616-053-3
- Cas Number:
- 74149-73-8
- Molecular formula:
- C19 H18 N4 O5
- IUPAC Name:
- 4-methoxy-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-2-nitrophenyl]benzamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Yellowish odorless powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- Total hardness from 0.01 to 0.5 °F.
- pH:
- At the start of test, pH value oscillated between 7.20 and 7.29; after 48 hours of incubation and exposure to animals, ranged between 7.21 and 7.40.
- Dissolved oxygen:
- At the start of test, dissolved oxygene concentration ranged from 6.0 mg/l and 6.3 mg/l; after 48 hours of incubation and exposure to animals renged between 5.6 mg/l and 5.9 mg/l.
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 1.06 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Test substance has an EC50 > 100 mg/l at 48 h.
- Executive summary:
The test substance Nitropyridazinone has an EC50 > 100 mg/l at 48 h.
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