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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1 (reliable without restriction)
according to guideline
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method
Limit test:
Route of administration:
oral: gavage
other: 0.5% methylcellulose aqueous solution
Starting dose level : 2000 mg/kg (1874 mg/kg of active ingredient)
Treatment : 2000 mg/kg (2043 of active ingredient based on a final purity of 93,7%)
No. of animals per sex per dose:
Control animals:
Dose descriptor:
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
No unscheduled deaths occured during the study
Clinical signs:
other: No clinical signs were observed in any animals

Pathology :

No test item related changes were seen at necroscopy, 14 days after a single oral administration of the test item at 2000 mg/kg.

Interpretation of results:
not classified
Migrated information Criteria used for interpretation of results: EU
Under the experimetal conditions of this study, the oral LD50 of the test item, Tocopheryl Glucoside, was higher than 2000 mg/kg in rats. Therefore, the test item should not be classified as toxic by oral route according the crieria of CLP regulation.
Executive summary:

The objective of the study was to evaluate the potential acute toxicity of the test item, Tocopheryl Glucoside, following a single oral administration (gavage) in rats. The study was conducted according the OECD guideline n°423.

The test item was administred once by oral route (gavage) to two groups of three fasted female Sprague-Dawley rats under a dosage volume of 10 mL/kg. The test item was prepared in a 0.5% methylcellulose aqueous solution at the dose level of 2000 mg/kg.

Each animal was observed at least once a day for mortality and clinical signs for 15 days. Body weight was recorded on day 1 and then on days 8 and 15. At the end of the study, the animals were sacrified and submitted for a macroscopic post-mortem examination.

Under the experimental conditions of the study, the oral LD50 of the test item aws higher than 2000 mg/kg in rats.

Therefore, the test item should not be classified as toxic by oral route according to the criteria of CLP regulation.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

Justification for classification or non-classification

Only acute oral toxicity study was conduced and show no adverse effects and no mortality after a single oral administration of 2000 mg/kg of test item in rats.