Registration Dossier
Registration Dossier
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EC number: 926-606-3 | CAS number: 1185314-26-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1999-01-18 to 1999-02-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The Non GLP study was conducted in accordance with the official OECD guideline 105 (1995).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- (July, 1995)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- (December, 1992)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Mucosolvan HBr
- IUPAC Name:
- Mucosolvan HBr
- Test material form:
- other: solid
- Details on test material:
- - Name of test material (as cited in study report): Mucosolvan HBr
- Physical state: Beige solid
- Storage condition of test material: at room temperature in the dark
- Stability under storage conditions: stable
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 6.5 g/L
- Temp.:
- 20 °C
- pH:
- 3.3
Any other information on results incl. tables
An excess of test substance was stirred with double distilled water for 24 days at room temperature. After centrifugation, the concentration of Mucosolvan HBr in the water phase was determined to be 6.50 g/L (mean value of all measurements). Because no significant differences were observed between the concentrations analysed after the second and third centrifugation step, it was concluded that all undissolved test substance had been removed after two centrifugation steps.
The HPLC chromatograms of the pretreated water samples were comparable with the chromatograms of the calibration solutions. The chromatograms of the pretreated blank water sample showed no peak with the same retention as the test substance.
The pH value of the three times centrifuged water sample was 3.3.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
In conclusion, the water solubility of Mucosolvan HBr at room temperature is 6.50 g/L.
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