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EC number: 432-690-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Subchronic toxicity after repeated oral exposure (gavage) was evaluated on the basis of a 90 day study according to OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity in Rodents) in rats (Sprague-Dawley; male/female) with daily exposure.
The dose range was:
Low: 5 mg/kg bw/day (actual ingested)
Medium: 50 mg/kg bw/day (actual ingested)
High: 750 mg/kg bw per day ; reduced to 500 mg/kg bw/day on day 56 due to severe effects (actual ingested)
Parameters examined were: Mortality, clinical signs, FOB, body weights, food consumption, clinical chemistry, hematology, necropsy, histopathology
Dermal exposure: The test material is a highly polar salt with a poly-anion of high molecular weight. It is used exclusively in aqueous solutions and completely ionised. Therefore, a significant skin penetration (bioavailability) and adverse effects via dermal exposure are not expected. Additionally the test material did show adverse systemic effects only after high doses (500-750 mg/kg bw) by oral gavage for prolonged periods and a structurally closely related substance did not cause skin irritation or sensitisation. Thus, no adverse effects are expected after dermal exposure with low bio-availability and no in vivo study (animal use) is justified.
Inhalation: The test material is produced and handled in industry exclusively in aqueous solutions. There are no spraying operations. Thus neither exposure nor risks are expected via the inhalation route.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 50 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
The broad and unspecific spectrum of findings in a large number of organs indicate an unspecific disturbation of well being of the animals by the application of high doses of the substance ov
er an extended period of time. The main targets most probably are liver and kidneys as these organs handle and excrete xenobiotic material. Most of the other changes can be interpreted as secondary effects of the reduced performance of these organs.As no effects were detected at the mid and low dose levels the effects in the high dose group are seen as an effect of metabolic overload of the rat organism.
Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: hematopoiesis; cardiovascular / hematological: lymph nodes; cardiovascular / hematological: spleen; digestive: liver; respiratory: lung; urogenital: kidneys; urogenital: prostate; urogenital: testes
Justification for classification or non-classification
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