Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Citation:
Brady, A., H. Stack, AND M. Waters. GENETIC TOXICOLOGY OF BENZOIN AND CAPROLACTAM. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/384 (NTIS PB90216151), 1989.

Key value for chemical safety assessment

Justification for classification or non-classification

Additional information

Based on animal carcinogenesis studies, benzoin has been classified as noncarcinogens. The genetic toxicity of the compound has been thoroughly evaluated in short-term in vitro bioassays. Genetic activity profiles and corresponding data listings and summaries are presented for benzoin. Generally weak positive responses were obtained with benzoin only in mammalian cell mutagenesis and cell transformation assays. Since the chemical structure of benzoin do not suggest the potential for genotoxicity these responses may be associated with nonspecific toxicity. The overwhelming majority of short-term test data suggest that, in accordance with animal cancer data, benzoin is not genotoxic.