Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Short description of key information:
In vitro, the substance reacts with DNA.
DNA damages are caused in various organisms, cells, and test systems e.g.
- Mutation is caused by the substance in bacteria and in plant cells.
- Mitotic recombination is caused by the substance in yeast.
- Chromosomal aberrations, sister chromatid exchanges and cell transformation are caused by the substance In cultured mammalian cells.
- DNA strand breaks are caused by the substance in vivo in rat brain cells.
(Based on data compiled by IARC 1999)

Endpoint Conclusion: Adverse effect observed (positive)

Justification for classification or non-classification

classification required (H350)