Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Review paper

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1997
Report date:
2007

Materials and methods

Test guideline
Guideline:
other: No data
Deviations:
not specified
Principles of method if other than guideline:
No data
GLP compliance:
not specified
Test type:
other: No data

Test material

Constituent 1
Chemical structure
Reference substance name:
2-propylvaleric acid
EC Number:
202-777-3
EC Name:
2-propylvaleric acid
Cas Number:
99-66-1
Molecular formula:
C8H16O2
IUPAC Name:
2-propylpentanoic acid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Dose descriptor:
LD50
Effect level:
ca. 670 mg/kg bw
Mortality:
No data
Clinical signs:
No data
Body weight:
No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Valproic acid has a reported LD50 (oral rat) of 670mg/kg