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EC number: 634-598-5 | CAS number: 106565-71-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Sept. 2013 - Oct. 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Fully documented study according to international guidelines and under GLP guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Principles of method if other than guideline:
- The temperature in the 30°C thermostat cabinet was in the range of 29.1-29.3°C
and not 30 ± 0.5°C as described in the study plan. This deviation was observed in
the pre-equilibration phase and not in the definitive equilibration phase of 20 ±
0.5°C. Thus, it had no influence on the outcome of the test. - GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- (3S,5R,8aS)-3-cyclohexyl-hexahydro-2H-[1,3]oxazolo[3,2-a]pyridine-5-carbonitrile
- EC Number:
- 634-598-5
- Cas Number:
- 106565-71-3
- Molecular formula:
- C14H16N2O1
- IUPAC Name:
- (3S,5R,8aS)-3-cyclohexyl-hexahydro-2H-[1,3]oxazolo[3,2-a]pyridine-5-carbonitrile
- Test material form:
- solid: crystalline
- Details on test material:
- Sample from Batch no. BS12010625;
additional analytical information provided in section 1.4
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- ca. 146 mg/L
- Temp.:
- 29.2 °C
- pH:
- > 7.1 - < 7.3
- Remarks on result:
- other: The last 24 h of the test were at 20.0 ± 0.5°C.
- Details on results:
- The measured concentrations were as follows:
144 mg/l after 48 h (i.e. 24 h at 29.2 ± 0.1°C and 24 h at 20.0 ± 0.5°C), pH 7.2
144 mg/l after 72 h (i.e. 48 h at 29.2 ± 0.1°C and 24 h at 20.0 ± 0.5°C), pH 7.1
149 mg/l after 96 h (i.e. 72 h at 29.2 ± 0.1°C and 24 h at 20.0 ± 0.5°C) pH 7.3
The water solubility of PAM-Oxazolopiperidine, calculated as the mean value of the
three determinations, is 146 mg/l.
The test is valid, since the concentrations of at least the last 2 vessels do not differ
by more than 15%.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
The water solubility of PAM-Oxazolopiperidine, calculated as the mean value of the
three determinations, is 146 mg/l. - Executive summary:
The water solubility of PAM-Oxazolopiperidine, was investigated by dissolving the test substance in tightly sealed test vessels at 30°C for at least 24 h and equilibration at 20°C for another 24 h, both by using a magnetic stirrer.
The initially added amount of test substance was 1 g per litre deionised water. All samples were filtrated before chemical analysis by HPLC using MILLIPORE AP15 glass fibre filters. The measured concentrations were as follows:
144 mg/l after 48 h (i.e. 24 h at 29.2 ± 0.1°C and 24 h at 20.0 ± 0.5°C), pH 7.2
144 mg/l after 72 h (i.e. 48 h at 29.2 ± 0.1°C and 24 h at 20.0 ± 0.5°C), pH 7.1
149 mg/l after 96 h (i.e. 72 h at 29.2 ± 0.1°C and 24 h at 20.0 ± 0.5°C) pH 7.3
The water solubility of PAM-Oxazolopiperidine, calculated as the mean value of the three determinations, is 146 mg/l.
The test is valid, since the concentrations of at least the last 2 vessels do not differ by more than 15%.
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