Registration Dossier
Registration Dossier
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EC number: 683-287-0 | CAS number: 877670-90-1
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- 2-(2-{1-[(2-methoxyphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl)benzoic acid
- EC Number:
- 683-287-0
- Cas Number:
- 877670-90-1
- Molecular formula:
- C18H17N3O5
- IUPAC Name:
- 2-(2-{1-[(2-methoxyphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl)benzoic acid
Constituent 1
Results and discussion
Particle size
- Percentile:
- D50
- Remarks on result:
- other: There were too few particles to allow accurate assessment of the mass median aaerodynamic diameter(migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.)
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- > 100 µm
- Distribution:
- 65.3 %
- No.:
- #2
- Size:
- > 10 - < 100 µm
- Distribution:
- 19.5 %
- No.:
- #3
- Size:
- > 5.5 - < 10 µm
- Distribution:
- ca. 12.09 %
- No.:
- #4
- Size:
- < 5.5 µm
- Distribution:
- ca. 3.11 %
Applicant's summary and conclusion
- Conclusions:
- Proportion of testitem having an inhalable particle size less than 100µm (Sieve) is 34.7%. Proportion of testitem having a Thoracic particle size less than 10µm is 15.2%. Proportion of test item having a respirable particle size less than 5.5µm is 3.11%
- Executive summary:
Particle size data have been acquired using a procedure designed to comply with the European Commission technical guidance document 'Particle Size Distribution, fibre length and diameter distribution' (June 1996), which satisfies the requirements of OECD guideline 110
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