Registration Dossier
Registration Dossier
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EC number: 200-291-6 | CAS number: 56-84-8
Endpoint summary
Administrative data
Description of key information
A study was performed to assess the skin irritation potential of L-Aspartic acid to the rabbit. The method followed was that described in EEC. Methods for the determination of toxicity, Annex to Directive 92/69/EEC (OJ No. L383A, 29.12.92), Part B, Method B.4. Acute toxicity (skin irritation). Three rabbits were each administered a single dermal dose of 0.5 g of the test substance and observed for four days. . No reactions were observed following a single semi-occlusive application of L-Aspartic acid to intact rabbit skin for four hours. L-Aspartic acid does not require labelling with the risk phrase R38 "Irritating to skin" in accordance with EEC Council Directive 79/831/EEC, Annex VI, Part lI(D) as described in Commission Directive 931211EEC.
Ergebni sse Elne einrnalige Aufbringung von 0,5 g L-Asparaginsäure auf die intakte Haut des Kaninchens 1ste bei keinern der im Versuch verwendeten Tiere Erytheme oder Oedeme aus. Der primäre Reizindex beträgt 0,0. Danach besitzt L-Asparaginsäure keine irritierenden Eigenschaften an der Ruckenhaut des Kaninchens. Die Einzeldaten sind in Tabelle 1 aufgefuhrt. Systeniisch-toxische Effekte traten nach dermaler Applikation des Prufproduktes nicht auf. Das Aligemeinbefinden der Versuchstiere war ungestort
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
A study was performed to assess the skin irritation potential of L-Aspartic acid to the rabbit. The method followed was that described in EEC. Methods for the determination of toxicity, Annex to Directive 92/69/EEC (OJ No. L383A, 29.12.92), Part B, Method B.4. Acute toxicity (skin irritation). Three rabbits were each administered a single dermal dose of 0.5 g of the test substance and observed for four days. . No reactions were observed following a single semi-occlusive application of L-Aspartic acid to intact rabbit skin for four hours. L-Aspartic acid does not require labelling with the risk phrase R38 "Irritating to skin" in accordance with EEC Council Directive 79/831/EEC, Annex VI, Part lI(D) as described in Commission Directive 931211EEC.
Ergebni sse Elne einrnalige Aufbringung von 0,5 g L-Asparaginsäure auf die intakte Haut des Kaninchens 1ste bei keinern der im Versuch verwendeten Tiere Erytheme oder Oedeme aus. Der primäre Reizindex beträgt 0,0. Danach besitzt L-Asparaginsäure keine irritierenden Eigenschaften an der Ruckenhaut des Kaninchens. Die Einzeldaten sind in Tabelle 1 aufgefuhrt. Systeniisch-toxische Effekte traten nach dermaler Applikation des Prufproduktes nicht auf. Das Aligemeinbefinden der Versuchstiere war ungestort
Justification for classification or non-classification
A study was performed to assess the skin irritation potential of L-Aspartic acid to the rabbit. The method followed was that described in EEC. Methods for the determination of toxicity, Annex to Directive 92/69/EEC (OJ No. L383A, 29.12.92), Part B, Method B.4. Acute toxicity (skin irritation). Three rabbits were each administered a single dermal dose of 0.5 g of the test substance and observed for four days. . No reactions were observed following a single semi-occlusive application of L-Aspartic acid to intact rabbit skin for four hours. L-Aspartic acid does not require labelling with the risk phrase R38 "Irritating to skin" in accordance with EEC Council Directive 79/831/EEC, Annex VI, Part lI(D) as described in Commission Directive 931211EEC.
Ergebni sse Elne einrnalige Aufbringung von 0,5 g L-Asparaginsäure auf die intakte Haut des Kaninchens 1ste bei keinern der im Versuch verwendeten Tiere Erytheme oder Oedeme aus. Der primäre Reizindex beträgt 0,0. Danach besitzt L-Asparaginsäure keine irritierenden Eigenschaften an der Ruckenhaut des Kaninchens. Die Einzeldaten sind in Tabelle 1 aufgefuhrt. Systeniisch-toxische Effekte traten nach dermaler Applikation des Prufproduktes nicht auf. Das Aligemeinbefinden der Versuchstiere war ungestort
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