Registration Dossier
Registration Dossier
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EC number: 700-287-9 | CAS number: 877179-04-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 3',4'-dichloro-5-fluoro-[1,1'-biphenyl]-2-amine
- EC Number:
- 700-287-9
- Cas Number:
- 877179-04-9
- Molecular formula:
- C12H8Cl2FN
- IUPAC Name:
- 3',4'-dichloro-5-fluoro-[1,1'-biphenyl]-2-amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Doses:
- 2000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- 2 groups of 3 female rats each
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- One animal died during the observation period.
- Clinical signs:
- other: Decreased motility, uncoordinated and high legged gait
- Gross pathology:
- No particular findings.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
LD50 oral of the test substance is >2000 mg/kg bw - equivalent to Category 5 of the GHS and
LD50 cut off 2500 mg/kg bw according to OECD Test Guideline 423.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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