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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
A reliable secondary source, summarising p-chlorophenylacetic acid, was used. However the primary sources were not revisited in order to verify their contents; for this reason reliability score 2 was used. The used secondary source has been updated on 2012; therefore it covers the most updated literature on the substance.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Chemical Summary: p-chlorophenylacetic acid (1878-66-6)
Year:
2012
Bibliographic source:
ACToR - Aggregated Computational Toxicology Resource
Reference Type:
secondary source
Title:
4-CHLOROPHENYLACETIC ACID
Year:
2012
Bibliographic source:
CCRIS - Chemical Carcinogenesis Research Information System

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No data
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Reference substance name:
p-chlorophenylacetic acid
EC Number:
217-521-6
EC Name:
p-chlorophenylacetic acid
Cas Number:
1878-66-6
IUPAC Name:
(4-chlorophenyl)acetic acid
Constituent 2
Reference substance name:
4-Chlorophenylacetic acid
IUPAC Name:
4-Chlorophenylacetic acid
Details on test material:
SMILE: c1cc(ccc1CC(=O)O)Cl

Method

Species / strainopen allclose all
Species / strain / cell type:
S. typhimurium TA 98
Additional strain / cell type characteristics:
not specified
Species / strain / cell type:
S. typhimurium TA 100
Additional strain / cell type characteristics:
not specified
Species / strain / cell type:
E. coli WP2 uvr A
Additional strain / cell type characteristics:
not specified
Metabolic activation:
not specified

Results and discussion

Test resultsopen allclose all
Species / strain:
S. typhimurium TA 98
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Species / strain:
S. typhimurium TA 100
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Species / strain:
E. coli WP2 uvr A
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

The test material did not produce any mutagen effects.