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Key value for chemical safety assessment

Additional information

In the non-GLP Ames test with zirconium di(acetate) oxide, performed according to a protocol similar to OECD guideline 471, the substance was tested in Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 using the plate incorporation and preincubation method (BASF AG, 1986). The tests were performed in triplicate, with and without metabolic activation, at test concentrations 0, 20, 100, 500, 2500 and 5000 μg/plate. The substance did not induce an increase in the number of revertants in any test, at any concentrations, with and without metabolic activation. No cytotoxicity was observed. Based on the results, the substance is considered to be negative in the Ames test.


Short description of key information:
In a non-GLP comparable to guideline Ames test, zirconium di(acetate) oxide did not induce an increase in the number of revertants in Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 with and without metabolic activation.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on the negative results in the Ames test, classification of zirconium di(acetate) oxide for genotoxicity is not warranted according to EU Directive 67/548 and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.