Registration Dossier
Registration Dossier
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EC number: 244-256-3 | CAS number: 21178-63-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, non-GLP but guideline-conform study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Chromium trioleate
- EC Number:
- 244-256-3
- EC Name:
- Chromium trioleate
- Cas Number:
- 21178-63-2
- Molecular formula:
- C18 H34 O2 .1/3 Cr
- IUPAC Name:
- chromium(3+) tris((9Z)-octadec-9-enoate)
- Details on test material:
- Name of the test substance used in the study report: Chrom(III)-Oleat
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- Mean weight of the rabbits: 2.82 kg
Singly housing in stainless steel cages with wire mesh walk floors (floor area: 40 x 51 cm; no bedding in the cages - sawdust in the waste trays). The rabbits were identified via ear tattoo. The animals were housed in fully air-conditioned rooms with a temperature ranging from 20 - 24°C and a relative humidity of 30 - 70%. The day/night rhythm was 12 h dark and 12 h light. The animals were offered a standardized rabbit diet (about 130 g per animal and per day) and drinking water (about 250 ml tap water per animal and day).
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 8 d
- Number of animals:
- 3
- Details on study design:
- Acclimatization period: at least 8 days before the beginning of the study with the same housing conditions as during the test period.
Clipping of the fur: at least 15 hours before the beginning of the study.
Application area: 2.5 x 2.5 cm
Application site: upper third of the back or flanks.
Removal of the test substance: at the end of the exposure period with Lutrol and Lutrol/water (1:1).
Readings: 30 - 6 min after removal of the test patches and 24, 48, 72 h and 8 d after the beginning of the application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 0.8
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- other: animals means: 0.3 in 2/3 animals, 1.7 in 1/3 animals
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 0.1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: animal means: 0.3 in 1/3 animals, 0 in 2/3 animals
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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