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Diss Factsheets
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EC number: 623-635-0 | CAS number: 27298-98-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 01 June 1984 to 05 June 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: guideline study with acceptable restrictions (e.g. test item concentrations not analytically verified)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
- Principles of method if other than guideline:
- - ASTM, standard practice for conducting acute toxicity tests with fishes, macroinvertebrates, and amphibians, E 729-80, 25 pp, 1980
- US EPA, methods for acute toxicity tests with fish, macroinvertebrates, and amphibians. Ecological Research Series (EPA-660/33-75-009), 61 pp, 1975 - GLP compliance:
- yes
Test material
- Reference substance name:
- L-α-methylbenzylamine
- EC Number:
- 220-098-0
- EC Name:
- L-α-methylbenzylamine
- Cas Number:
- 2627-86-3
- IUPAC Name:
- 1-phenylethanamine
- Reference substance name:
- L-alpha-methylbenzylamine
- IUPAC Name:
- L-alpha-methylbenzylamine
- Details on test material:
- - Name of test material (as cited in study report): PEA [L-(-)-alpha phenyl ethylamine]
- Physical state: colourless liquid
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: stock solution (18,000 mg/L; test substance in deionised water)
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: Fathead Minnow
- Source: SBI Wareham, Massachusetts Laboratory, USA
- Age at study initiation (mean and range, SD): 5 to 6 weeks
- Length at study initiation (length definition, mean, range and SD): 11-19 mm (13 ± 2 mm)
- Weight at study initiation (mean and range, SD): 0.01 to 0.06 g (0.02 ± 0.02 g)
- Feeding during test: no
ACCLIMATION
- Acclimation period: 14 d
- Acclimation conditions (same as test or not): similar, temperature range slightly lower (19 to 21 °C)
- Type and amount of food: live brine shrimp nauplii and/or commercial flake food
- Feeding frequency: daily
- Health during acclimation (any mortality observed): 0% in the 48-h period before test start
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 23 mg/L as CaCO3
- Test temperature:
- 21-23 °C
- pH:
- 7.0 to 9.4
- Dissolved oxygen:
- 5.6 to 9.6 mg/L
- Nominal and measured concentrations:
- nominal: 7.8, 13, 22, 36, 68, 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: 3.8-L glass test container, covered, fill volume: 3 L, water depth: 17 cm
- Aeration: none
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 3.3 fish/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted freshwater
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 14 h light/10 h dark
- Light intensity: fluorescent lighting, 450 foot candles
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- mortality after 24, 48, 72 and 96 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: < 2
- Justification for using less concentrations than requested by guideline: not applicable
- Range finding study
- Results used to determine the conditions for the definitive study: yes
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 17 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 13-22 mg/L
- Reported statistics and error estimates:
- LC50 determined using the following method: non-linear interpolation with 95% confidence limits estimated by binomial probability.
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Mortality:
Test item conc.
Cumulative mortality (%)
(nominal; mg/L)
24 h
48 h
72 h
96 h
0
0
0
0
0
7.8
0
0
0
0
13
0
0
0
0
22
100
100
100
100
36
100
100
100
100
60
100
100
100
100
100
100
100
100
100
pH and dissolved oxygen:
Test item conc.
pH (replicate A)
Dissolved oxygen (mg/L)
(nominal; mg/L)
initial
final
0
7.3
7.0
6.4 to 8.8
7.8
8.5
7.0
6.7 to 9.6
13
8.7
7.0
6.8 to 8.9
22
not measured
7.9
5.6
36
9.1
8.4
6.3 to 8.8
60
not measured
8.8
7.8 to 7.9
100
9.4
8.9
8.0 to 8.9
Other physicochemical parameters:
- specific conductivity: 150 to 165 µmhos/cm
- total hardness: 28 to 40 mg/L as CaCO3
- total alkalinity: 64 to 178 mg/L (increasing values with increasing test item concentration)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.