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Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1995
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995
Report date:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
A mixture of: ethyl (2R,3R)-3-isopropylbicyclo[2.2.1]hept-5-ene-2-carboxylate; ethyl (2S,3S)-3-isopropylbicyclo[2.2.1]hept-5-ene-2-carboxylate
EC Number:
427-090-8
EC Name:
A mixture of: ethyl (2R,3R)-3-isopropylbicyclo[2.2.1]hept-5-ene-2-carboxylate; ethyl (2S,3S)-3-isopropylbicyclo[2.2.1]hept-5-ene-2-carboxylate
Cas Number:
116044-44-1
IUPAC Name:
bis(ethyl (2R,3R)-3-(propan-2-yl)bicyclo[2.2.1]hept-5-ene-2-carboxylate)

Study design

Analytical monitoring:
yes
Duration of testopen allclose all
Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
10.5 - 13.7 mg/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
10.5 - 13.7 mg/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
10.5 - 13.7 mg/L

Results and discussion

Transformation products:
no

Any other information on results incl. tables

Less than 10% hydrolysis after 5 days at 50°C which equates to a half-life of greater than 1 year at 25°C.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Herbanate has been found to undergo less than 10% hydrolysis after 5 days at 50°C in pH 4, 7 and 9 buffer solutions.
The half-life at 25°C has been estimated and is given below:
pH Half-life
4 > 1 year
7 > 1 year
9 > 1 year

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