Registration Dossier
Registration Dossier
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EC number: 210-734-5 | CAS number: 622-40-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Key value for chemical safety assessment
Additional information
The inhibiting effect of 2 -morpholinoethanol (CAS 622 -40 -2) on the respiration activity of domestic activated sludge was assessed via a read-across approach since no experimental data are available for this substance. Test data for toxicity to microorganisms were taken from studies with other N-substituted morpholine structures.
The following results were considered:
4 -Acetylmorpholin (CAS 1696 -20 -4):
- BASF AG (1992; Study no. 91/1665/08/1): OECD 209: 30 min EC20 > 1000 mg/L
- BASF AG (1992; Study no. 91/1665/70/2): DIN 38412, Part 8: 16-h EC10 > 10000 mg/L
4 -Methylmorpholine (CAS 109 -02 -4):
- BASF AG (1991; 1/91/0270/08/1): OECD 209: 30 min. EC20 > 1000 mg/L
4 -Ethylmorpholine (CAS 100 -74 -3):
- BASF AG (1987; Study no. 01.451/86): similar to OECD 209 (industrial activated sludge): 30 min EC20 > 600 mg/L
- BASF AG (1990; Study no. 91/1890733): DIN 38412, Part 8: 16-h EC10 = 1151 mg/L
4 -Morpholinecarbaldehyde (CAS 4394 -85 -8):
- BASF AG (1987; Study no. 9/0553/87): DIN 38412, Part 8: 16-h EC10 > 2000 mg/L
Regarding these results, the toxicity to microorganisms is low. Therefore, the inhibition of the degradation activity of activated sludge is not anticipated when the substance is introduced in appropriately low concentrations.
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