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Diss Factsheets
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EC number: 240-934-8 | CAS number: 16893-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 25 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
Repeated dose toxicity has been tested for sodium fluoride. No studies are available for disodium hexafluorosilicate. Due to the presence of hydrolysable groups on its chemical structure, fluorosilicate anions are not expected to remain in solution long under environmental conditions. Instead, fluoride anions will be formed. Thus, the performance of such tests is unjustified, since there are reliable studies on sodium fluoride or hydrogen fluoride. Read-across to sodium fluoride is appropriate.
In a 28 day study on male and female rats which were feed by gavage with 0.0%, 0.0025%, 0.025% or 0.25% aqueous NaF (w/w), several effects, such as depression in mean cell haemoglobin, depression in total protein, increase of fluoride in urine, were observed.Male and female rats suffered a continuous exposure for a period of 6 months to NaF. This fact caused weight loss at dose =300ppm, fluorosis of the teeth and hyperplastia of the gastric mucosa of the stomach at 100 and 300 ppm. Bone and urine also increased their level of fluoride when fluoride concentration in drinking water increased.
Male and female mice were feed NaF for 6 month in a continuous exposure in drinking water. During this period some animals died after ingesting the highest dose, 600 ppm. Weight loss, fluorosis and effects on liver were observed. Increasing fluoride concentration in drinking water, fluoride content of bones and urine increased.
A study carried out for 2 years on rats and mices which were feed with NaF in drinking water showed that bones and teeth tend to accumulate fluoride. In addition, fluorosis in teeth was observed. However, these effects occurred using a much higher concentration of NaF than normally used in human drinking water. The presence of osteosarcomas was observed in some animals. However, this fact is not directly attributable to the presence of fluoride in drinking water.
EURAR HF 2001 reported that for the repeated dose toxicity via inhalation studies the available animal data set for HF permit the derivation of a NOAEL for repeated subchronic inhalatory exposure. The over-all NOAEL is taken form 91 day GLP study with female and male rats and amounts 0.72 mg HF/m3for 6 h per day 5 days per week exposure regimen with no adverse effects. At the next exposure level death, tissue irritation, dental malformations, haematological and biological changes and changes in several organ weights were observed. In humans prolonged intake of fluoride results in skeletal fluorosis. Exposure to 1.16 mg HF/m3for 6 hr/d may result in some discomfort, slight stinging sensation in eyes and facial skin and slight irritation of the nasal mucosa. This concentration can be considered as a LOAEL for inhalatory exposure. Beneficial effects like prevention of dental carries after low fluoride intake have been observed. On the other hand, excessive fluoride intake can cause dental fluorosis (dental lesions) and osteofluorosis (bone structural changes).
Repeated dose toxicity: via oral route - systemic effects (target organ) cardiovascular / hematological: blood coagulation; digestive: liver; digestive: stomach; other: bone
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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