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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 240-934-8 | CAS number: 16893-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 10 mg/kg bw/day
Additional information
Toxicity to reproduction has been tested for sodium fluoride. No studies are available for disodium hexafluorosilicate. Due to the presence of hydrolysable groups on its chemical structure, fluorosilicate anions are not expected to remain in solution long under environmental conditions. Instead, fluoride anions will be formed. Thus, the performance of such tests is unjustified, since there are reliable studies on sodium fluoride or hydrogen fluoride. Read-across to sodium fluoride is appropriate.
Sodium fluoride in drinking water of Sprague-Dawley rats at levels up to 250 ppm (equivalent to 28.4 mg sodium fluoride/kg body weight/day or 12.8 mg fluoride/kg body weight/day) had no adverse effects on reproduction throughout three generations. No cumulative toxic effects were observed in the three generations.Short description of key information:
No effects were observed.
Effects on developmental toxicity
Description of key information
No significant effects were oserved.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 14 mg/kg bw/day
Additional information
A concentration of 175 ppm sodium fluoride in drinking water of a parental (P) and two filial generations (F1 and F2) of rats did not produce developmental effects and is considered a no-observed effect concentration for developmental toxicity. A concentration of 250 ppm sodium fluoride in drinking water of a parental (P) and two filial generations (F1 and F2) of rats caused statistically significant decreased ossification of the hyoid bone in F2 fetuses and is considered an effect concentration for developmental toxicity. No definative treatment-related effects on foetal growth or on the incidence of external, visceral, or skeletal abnormalities at levels of sodium fluoride up to and including 250 ppm (25.1 mg/kg/day) were found. Maternal exposure to sodium fluoride at conentrations up to 400 ppm (approximately 29 mg/kg/day) during organogenesis (gestation days 6 to 19) did not significantly affect the frequency of postimplantation loss, mean fetal body weight/litter, or external, visceral or skeletal malformations in the rabbit.
Justification for classification or non-classification
No classification is proposed, since data obtained from reliable studies show the absence of developmental toxicity or reproductive toxicity of fluoride.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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