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Diss Factsheets
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EC number: 231-635-3 | CAS number: 7664-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published study
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute and chronic respiratory effects of occupational exposure to ammonia
- Author:
- Holness, D.G., Purdham, J.T., Nethercott, J.R.
- Year:
- 1 989
- Bibliographic source:
- American Industrial Hygiene Association Journal, 50(12):646-650
Materials and methods
- Study type:
- medical screening
- Endpoint addressed:
- repeated dose toxicity: inhalation
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The chronic effects of ammonia inhalation on industrial workers were examined
- GLP compliance:
- not specified
- Remarks:
- : not applicable to this type of study
Test material
- Reference substance name:
- Ammonia, anhydrous
- EC Number:
- 231-635-3
- EC Name:
- Ammonia, anhydrous
- Cas Number:
- 7664-41-7
- Molecular formula:
- H3N
- IUPAC Name:
- ammonia
- Details on test material:
- Ammonia, used in the production of sodium carbonate using the Solvvay process.
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Details on study design:
- The results of an investigation in which the chronic effects of ammonia (7664417) on industrial workers exposed to levels less than 50 parts per million (ppm) were assessed. The acute effects of ammonia exposure on the respiratory and integumentary systems of these workers was also examined. The workers were exposed in the production of sodium-carbonate (497198) (soda-ash) using the Solvay process. Fifty two of the available 64 workers agreed to participate. These workers were assessed on the first workday of the work week and on the last workday of the same week. A comparison group consisted of 31 workers with a mean exposure of 0.3 to 0.1ppm ammonia.
Results and discussion
- Results:
- The exposed workers and comparisons experienced ammonia levels of 9.2 and 0.3ppm, respectively. Three workers were noted to have time weighted average ammonia concentrations in excess of 25ppm. There were no differences between the two groups in the reporting of respiratory or cutaneous symptoms, sense of smell, baseline lung function, or change in lung function over a work shift at the beginning and end of a work week. No relationships were observed between level or length of ammonia exposure and lung function results.
Any other information on results incl. tables
There were no differences in symptoms, sense of smell, acute changes in lung function during exposure, or changes in baseline lung function in exposed workers compared to control workers. There was no relationship demonstrated between the level of exposure to ammonia (average of 9.2 ppm (= 6.4 mg/m3) and acute changes in lung function over the work shift. No chronic effects on lung function that could be related to the length of exposure were demonstrated.
The chronic effects of ammonia on industrial workers to levels less than 50 ppm were assessed. The study also examined the acute effects of ammonia exposure on the respiratory system, eyes, and skin. A total of 52 soda ash plant workers, 6 maintenance workers, and 35 control workers were assessed. All participants were male, mean age 40.5 years, and plant tenure approximately 15 years. Exposed workers were assessed on 2 workdays; on the first and last workdays of their workweek. The study was carried out over a period of one week. Maintenance workers were assessed on one workday in the middle of their workweek. The control group was assessed twice on two separate days during the same week. All participants completed a questionnaire regarding past occupational exposures, working conditions, smoking history, and respiratory symptoms and eye and skin complaints. Each participant's sense of smell was assessed at the beginning and end of the workweek. Spriometry was performed at the beginning and end of each work shift on both test days so that each worker had four tests done. The average concentration of ammonia to which workers were exposed during their work shifts was determined using NIOSH-recommended procedures. Exposed and control workers were sampled over one work shift. The average sample collection period was 8.4 hours. The mean time-weighted average (TWA) ammonia exposure of the exposed group was 9.2 ppm, 0.3 ppm for the control group. Three workers were exposed to TWA concentrations in excess of 25 ppm.
Applicant's summary and conclusion
- Conclusions:
- No adverse health effects are reported in workers exposed to ammonia at concentrations (TWA) of up to 25 ppm and higher.
- Executive summary:
The chronic effects of ammonia inhalation on industrial workers were examined. The exposed workers and control comparisons experienced ammonia levels of 9.2 and 0.3 ppm, respectively. Three workers were noted to have time weighted average ammonia concentrations in excess of 25ppm. There were no differences between the two groups in the reporting of respiratory or cutaneous symptoms, sense of smell, baseline lung function, or change in lung function over a work shift at the beginning and end of a work week. No relationships were observed between level or length of ammonia exposure and lung function results.
It is therefore concluded that exposure to ammonia at concentrations of up to 25 ppm is without adverse effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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