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EC number: 206-992-3 | CAS number: 420-04-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- other: review
- Adequacy of study:
- supporting study
- Study period:
- April 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
- Study type:
- other: review
- Endpoint addressed:
- repeated dose toxicity: oral
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- no
Test material
- Reference substance name:
- Cyanamide
- EC Number:
- 206-992-3
- EC Name:
- Cyanamide
- Cas Number:
- 420-04-2
- Molecular formula:
- CH2N2
- IUPAC Name:
- cyanamide
- Test material form:
- other: aqueous solution
- Details on test material:
- Different substances.
for this record of concern: COLME-Solution
equal to 6% aqueous solution of cyanamide
Constituent 1
Method
- Type of population:
- other: mainly patients suffering from alcohl disease
- Ethical approval:
- other: Cyanamide is approved as deterrent for alcoholics. All results are taken form case reports in literature.
Results and discussion
- Results:
- Gloxhuber (2006; Doc. No. 581-011; MIIA 5.9.3/01) summarized and comprehensively evaluated the available literature in order to establish a NOAEL for human. As the evaluated reports on long-term effects were only suitable for a daily uptake of approx. 100 mg cyanamide, a NOAEL of 100 mg cyanamide/day was deduced, which corresponds to 1.4 mg cyanamide/kg bw/day under the prerequisite that the persons do not simultaneously consume alcohol (body weight 70 kg). Gloxhuber concluded that the intake of minor amounts (primarily via inhalation or percutaneous route), which might occur in agricultural or chemical production, can not be considered as harmful, even if the exposure lasts for a longer period of time. This conclusion is based on medical experience, provided that the absorbed quantities are below the limit doses used in the alcohol aversion therapy.
Applicant's summary and conclusion
- Conclusions:
- Gloxhuber summarized and comprehensively evaluated the available literature and established a NOAEL for human of approx. 100 mg cyanamide, which corresponds to 1.4 mg cyanamide/kg bw/day.
- Executive summary:
Gloxhuber (2006; Doc. No. 581-011; MIIA 5.9.3/01) summarized and comprehensively evaluated the available literature in order to establish a NOAEL for human. As the evaluated reports on long-term effects were only suitable for a daily uptake of approx. 100 mg cyanamide, a NOAEL of 100 mg cyanamide/day was deduced, which corresponds to 1.4 mg cyanamide/kg bw/day under the prerequisite that the persons do not simultaneously consume alcohol (body weight 70 kg). Gloxhuber concluded that the intake of minor amounts (primarily via inhalation or percutaneous route), which might occur in agricultural or chemical production, can not be considered as harmful, even if the exposure lasts for a longer period of time. This conclusion is based on medical experience, provided that the absorbed quantities are below the limit doses used in the alcohol aversion therapy.
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