Registration Dossier
Registration Dossier
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EC number: 209-193-8 | CAS number: 558-30-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979 - 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- BASF-Test, see details in the section "Any other information on materials and methods incl. tables".
- GLP compliance:
- no
- Remarks:
- study was performed prior to GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2-dimethyloxirane
- EC Number:
- 209-193-8
- EC Name:
- 2,2-dimethyloxirane
- Cas Number:
- 558-30-5
- Molecular formula:
- C4H8O
- IUPAC Name:
- 2,2-dimethyloxirane
- Details on test material:
- Please refer to the section "confidential details on test material" below.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: young adult (based on body weight)
- Weight at study initiation: 250 g (male), 200 g (female)
IN-LIFE DATES: From: 1979-07-12 To: 1979-07-26
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST MATERIAL
- Amount applied: 2.41 mL/kg bw or 4.81 mL/kg bw
- Concentration: pure
- Constant volume or concentration used: yes
- The test substance was applied in unaltered form
- Application area: approximately 50 cm² - Duration of exposure:
- No data
- Doses:
- 2000, 4000 mg/kg bw
- No. of animals per sex per dose:
- 3 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of application and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, macroscopical examination
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Not noticed.
- Clinical signs:
- other: Not observed.
- Gross pathology:
- Examined organs without findings.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
