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EC number: 289-296-2 | CAS number: 87061-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28th May to 22nd June 1999 for males, 2nd July to 28th July for females
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted in 1999 in accordance with OECD guideline 420 although not in accordance with GLP. The batch number (807007) and purity (100%) are both noted in the report. A statement of authentication is also provided in the report in lieu of a more formal Quality Assurance procedure. The study is well reported with regards to both the methodology and results. One animal died during the study but no explanation attributing the cause of death is made within the report. There were no abnormalities detected upon necropsy. Due to the lack of observed effects this deviation is not considered to affect the reliability of the study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol
- EC Number:
- 289-296-2
- EC Name:
- 3-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]propane-1,2-diol
- Cas Number:
- 87061-04-9
- Molecular formula:
- C13H26O3
- IUPAC Name:
- 3-{[5-methyl-2-(propan-2-yl)cyclohexyl]oxy}propane-1,2-diol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7 weeks old
- Weight at study initiation: 215-252 g for males and 171-195 g for females
- Fasting period before study: Overnight (18 to 20 hours)
- Housing: Group caged by sex, 2 or 3 animals in each cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 25 days for males, 10 days for females
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 °C
- Humidity (%): 30-70 %
- Air changes (per hr): Approximately 15 per hour
- Photoperiod (hrs dark / hrs light): 12 hours light/12 hours dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- soya oil
- Details on oral exposure:
- VEHICLE
- Amount of vehicle: 1 mL/100 g bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 males and 5 females dosed with the test material
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: The animals were observed at least once daily, the animals were weighed prior to dosing and on days 7 and 15
- Necropsy of survivors performed: Yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occcurred in the males dosed with the test material. One female was found dead on day 2.
- Clinical signs:
- other: There were no treatment related clinical signs.
- Gross pathology:
- There were treatment related necropsy findings. No abnormaltities of the abdominal and thoracic cavities were observed. No abnormalities were observed in animals sacrificed at the end of the study.
Any other information on results incl. tables
Table 1: Results
Sex |
Dose (mg/kg) |
Number of Rats |
Age and Weight (g) at Dosing |
Mortality |
Male |
2000 |
6 |
7 weeks old, 215-252 g |
0/6 |
0 (control) |
1 |
0/1 |
||
Female |
2000 |
5 |
7 weeks old, 171-195 g |
1/5 |
0 (control) |
1 |
0/1 |
||
Combined |
2000 |
11 |
7 weeks old, 171-252 g |
1/11 |
0 (control) |
2 |
0/2 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the test, the LD50 of the test material was found to be greater than 2000 mg/kg bw in male and female Wistar rats.
- Executive summary:
In a study conducted to OECD 420, the acute oral toxicity of the test material was investigated in male and female Wistar rats using a limit dose of 2000 mg/kg bw. Only one mortatlity was noted during the course of the study, and no treatment related changes were apparent. Under the conditions of the test, the LD50 of the test material was determined to be greater than 2000 mg/kg bw.
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