Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 204-429-6 | CAS number: 120-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: No method followed
- Type of information:
- other: Comment in the SIDS dossier
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The SIDS dossier does not identify a study for skin sensitisation.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- None
- GLP compliance:
- not specified
- Remarks:
- Not applicable
- Type of study:
- not specified
Test material
- Reference substance name:
- 2,4-dichlorophenol
- EC Number:
- 204-429-6
- EC Name:
- 2,4-dichlorophenol
- Cas Number:
- 120-83-2
- Molecular formula:
- C6H4Cl2O
- IUPAC Name:
- 2,4-dichlorophenol
- Details on test material:
- Not applicable
Constituent 1
In vivo test system
Test animals
- Species:
- other: Not applicable
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Not applicable
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: Not applicable
- Vehicle:
- no data
- Remarks:
- Not applicable
- Concentration / amount:
- Not applicable
Challengeopen allclose all
- Route:
- other: Not applicable
- Vehicle:
- no data
- Remarks:
- Not applicable
- Concentration / amount:
- Not applicable
- No. of animals per dose:
- Not applicable
- Details on study design:
- Not applicable
- Challenge controls:
- Not applicable
- Positive control substance(s):
- not required
- Remarks:
- Not applicable
Study design: in vivo (LLNA)
- Concentration:
- Not applicable
- No. of animals per dose:
- Not applicable
- Details on study design:
- Not applicable
- Statistics:
- Not applicable
Results and discussion
- Positive control results:
- Not applicable
In vivo (non-LLNA)
Results
- Reading:
- other: Not applicable
- Group:
- other: Not applicable
- Dose level:
- Not applicable
- Clinical observations:
- Not applicable
- Remarks on result:
- other: Reading: other: Not applicable. Group: other: Not applicable. Dose level: Not applicable. Clinical observations: Not applicable.
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: Not applicable
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Not applicable
Any other information on results incl. tables
Not applicable
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- No study has been identified and the skin sensitistaion potential has not been assessed since the substance is corrosive.
- Executive summary:
No study was identified for skin sensitisation potential with 2,4-DCP. It may not be achievable since the substance is corrosive. In addition, the evaluation of the skin sensitisation potential may be unwanted due to the mandatory prevention of exposure. Therefore skin sensitisation potential has not been assessed. It is not considered to be prudent owing to the desire to avoid any contact with corrosive substances.
Chloracnea has been reported upon human exposure to a mixture of chlorophenols containing 2,4 -dichlorophenol.
Bleiberg J.et al(1964) Arch.Dermatol., 89: 793-797, Poland A.P.et al.(1971) Arch. Environ. Health, 22: 316-327
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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