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Diss Factsheets
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EC number: 202-225-1 | CAS number: 93-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study. Non-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF Test
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- veratrylcyanid
- IUPAC Name:
- veratrylcyanid
- Reference substance name:
- 78/834
- IUPAC Name:
- 78/834
- Details on test material:
- Veratrylcyanid; no data on purity given in the report
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - diet: Herilan MRH-Haltung; H. Eggersmann KG
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- - way of application: oral (not further specified)
- form of application: suspension
- formulation in: ß.5% aqueous carboxymethyl cellulose
- fasting before application: 15 - 20 h
- observation period: 14 days
- max. volume applied: 10 mL/kg bw.
- range of concentration: 1.00-5.64 % (g/v) - Doses:
- 100, 147, 215, 316, 464 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not described in the protocol
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 230 mg/kg bw
- Mortality:
- Mortality in male rats after 1 hour/1 day/2 days/7 days/14 days:
- 464 mg/kg bw dose level: 3/5/5/5/5
- 316 mg/kg bw dose level: 0/4/4/4/4
- 215 mg/kg bw dose level: 0/3/3/3/3
- 147 mg/kg bw dose level: 0/0/0/0/0
- 100 mg/kg bw dose level: 0/0/0/0/0
Mortality in female rats after 1 hour/1 day/2 days/7 days/14 days:
- 464 mg/kg bw dose level: 1/5/5/5/5
- 316 mg/kg bw dose level: 0/4/4/4/4
- 215 mg/kg bw dose level: 0/2/2/2/2
- 147 mg/kg bw dose level: 0/0/0/0/0
- 100 mg/kg bw dose level: 0/0/0/0/0 - Clinical signs:
- - 464 mg/kg bw dose level: dyspnoe, apathy, abnormal position, staggering, atonia, no reflex on pain, tremor, poor general state, salivation, dermal erythema, convulsions.
- 316 mg/kg bw dose level: dyspnoe, apathy, aggressivness, abnormal position, staggering, tremor, convulsions, dermal erythema, poor general state, salivation.
- 215 mg/kg bw dose level: dyspnoe, apathy, abnormal position, staggering, no reflex on pain, convulsion, piloerection, dermal erythema, exsiccosis, salivation, poor general state.
- 147 mg/kg bw dose level: dyspnoe, apathy, staggering, tremor, piloerection, dermal erythema, poor general state.
- 100 mg/kg bw dose level: dyspnoe, apathy, staggering, dermal erythema, poor general state. - Body weight:
- Mean body weight [g] in male rats before application/2-4 days after appl./7 days after appl./13 days after appl.
- 464 mg/kg bw dose level:----
- 316 mg/kg bw dose level: 200/213/246/247
- 215 mg/kg bw dose level: 160/193/233/271
- 147 mg/kg bw dose level: 210/231/257/290
- 100 mg/kg bw dose level: 210/218/253/293
Mean body weight [g] in female rats before application/2-4 days after appl./7 days after appl./13 days after appl.
- 464 mg/kg bw dose level:----
- 316 mg/kg bw dose level: 170/169/182/211
- 215 mg/kg bw dose level: 170/185/204/201
- 147 mg/kg bw dose level: 170/175/198/182
- 100 mg/kg bw dose level: 170/183/197/210
Any other information on results incl. tables
Mortality was 5/10, 8/10 and 10/10 in the groups administered 215, 316 and 464 mg/kg bw, respectively. Deaths were approximately equally divided by sex and occurred within the first day after dosing.
Signs of toxicity were observed at all dose levels and included dyspnea, apathy, aggressive behavior, anomal position, staggering, atony, loss of pain reflex, narcotic-like state, tremor, spastic gait, tonus with bending, tonic convulsion, tonic-clonic convulsion, piloerection, skin redness, exsiccosis, salivation and poor general state. Body weight gains were within the expected range.
Post-mortem examination of the decedents revealed changes of the heart (acute ventricular dilatation, acute congestive hyperemia), brightened liver and slight acute distention of the lungs. No pathological findings were observed in survivors sacrificed at the end of the observation period.
Applicant's summary and conclusion
- Conclusions:
- Based on the results of this study, the test substance veratrylcyanid has to be classified "Acute oral Tox Cat. 3" and R22 according to Regulation (EU) No. 1272/2008 and Directive 67/548/EEC, respectively.
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