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Diss Factsheets
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EC number: 202-225-1 | CAS number: 93-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study (OECD 405). Non-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Method: according to Fed. Reg. 38 (187), §1500.42, p. 27029, 27-Sep-1973
- GLP compliance:
- no
Test material
- Reference substance name:
- veratrylcyanid
- IUPAC Name:
- veratrylcyanid
- Reference substance name:
- 78/834
- IUPAC Name:
- 78/834
- Details on test material:
- Veratrylcyanid; no data on purity given in the report
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- - diet: SSNIFF, Intermast
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 72 h
- Number of animals or in vitro replicates:
- 6 (1 female and 5 males).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- other: animal #1 - #6
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: individual scores: 0 - 0 - 0
- Irritation parameter:
- iris score
- Basis:
- other: animal #1 -#6
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Remarks on result:
- other: individual scores: 0 - 0 - 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 1.7
- Max. score:
- 3
- Reversibility:
- other: A full reversibility of the symptoms within 21 days can be expected.
- Remarks on result:
- other: individual scores: 2 - 2 - 1
- Irritation parameter:
- chemosis score
- Basis:
- animal: animal #1 - #6
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: individual scores: 0 - 0 - 0
- Irritation parameter:
- conjunctivae score
- Basis:
- other: animal #2, #4, #5 and #6
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- other: A full reversibility of the symptoms within 21 days can be expected.
- Remarks on result:
- other: individual scores: 1 - 1 - 1
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 0.7
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: individual scores: 1 - 1 - 0
Any other information on results incl. tables
Readings |
Animal |
Cornea |
Iris |
Conjunctiva |
Additional findings |
|||
op |
ar |
red |
ch |
di |
||||
24 h |
1 |
0 |
0 |
0 |
2 |
0 |
1 |
|
2 |
0 |
0 |
0 |
1 |
0 |
0 |
||
3 |
0 |
0 |
0 |
1 |
0 |
0 |
||
4 |
0 |
0 |
0 |
1 |
0 |
0 |
||
5 |
0 |
0 |
0 |
1 |
0 |
1 |
||
6 |
0 |
0 |
0 |
1 |
0 |
0 |
||
48 h |
1 |
0 |
0 |
0 |
2 |
0 |
1 |
|
2 |
0 |
0 |
0 |
1 |
0 |
0 |
||
3 |
0 |
0 |
0 |
1 |
0 |
0 |
||
4 |
0 |
0 |
0 |
1 |
0 |
0 |
||
5 |
0 |
0 |
0 |
1 |
0 |
0 |
||
6 |
0 |
0 |
0 |
1 |
0 |
0 |
||
72 h |
1 |
0 |
0 |
0 |
1 |
0 |
0 |
|
2 |
0 |
0 |
0 |
1 |
0 |
0 |
||
3 |
0 |
0 |
0 |
0 |
0 |
0 |
||
4 |
0 |
0 |
0 |
1 |
0 |
0 |
||
5 |
0 |
0 |
0 |
1 |
0 |
0 |
||
6 |
0 |
0 |
0 |
1 |
0 |
0 |
||
Mean 24-72 h |
1-6 |
0 |
0 |
0 |
1.1 |
0 |
0.2 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- Based on the results of this study, the test substance vertarylcyanid does not need to be classified according to Regulation (EU) No. 1272/2008 and Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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