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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 201-185-2 | CAS number: 79-20-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Remarks:
- in human
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Principles of method if other than guideline:
- 10% methylacetat induction and challenge
- GLP compliance:
- not specified
- Type of study:
- other: maximization test
- Justification for non-LLNA method:
- Study performed in 1979, LLNA method was not available.
- Species:
- other: human
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals and environmental conditions:
- In a human maximization study, 25 healthy, male (11) and (14) female subjects aged 18-31 years old were used. Test material was applied under occlusion to the same site on the volar forearm ot back of all subjects for five alternate-day 48 hour periods. The patch site was pre-treated for 24 hours with 2.5% aqueous sodium lauryl sulfate (SLS) under occlusion. Prior to challenge, 5 to 10% SLS was applied to test site for one hour before application of test material. Challenge site was read on patch removal and 24 hours thereafter.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 10%
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Clinical observations:
- no sensitisation observed
- Remarks on result:
- no indication of skin sensitisation
- Reading:
- 1st reading
- Group:
- negative control
- Remarks on result:
- not measured/tested
- Remarks:
- There is no negative control group as it is a maximisation test with 25 volunteers.
- Reading:
- 1st reading
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Remarks:
- There is no positive control group as it is a maximisation test with 25 volunteers.
- Interpretation of results:
- not sensitising
- Conclusions:
- The study result meets the long experience from human exposure to humans. The test method of a maximization test is justified in this case.
In this human maximization study no skin sensitisation was observed. - Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Remarks:
- review of literature and assessment of available human, animal and alternative data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Principles of method if other than guideline:
- review of literature and assessment of available human, animal and alternative data
- GLP compliance:
- not specified
- Type of study:
- other: review of literature and assessment of available human, animal and alternative data
- Justification for non-LLNA method:
- Study performed in 2003; when LLNA has not been an accepted OECD test method.
- Species:
- other: human volunteers
- Reading:
- other: not applicable as summary of several individuel studies
- Group:
- test chemical
- Dose level:
- not applicable as summary of several individuel studies
- No. with + reactions:
- 0
- Total no. in group:
- 25
- Clinical observations:
- No senstisation observed in studies. No sensitizing properties from experience
- Remarks on result:
- other: Summary of several individuel studies
- Remarks:
- Reading: other: not applicable as summary of several individuel studies. Group: other: not applicable as summary of several individuel studies. Dose level: not applicable as summary of several individuel studies. No with. + reactions: 0.0. Total no. in groups: 25.0. Clinical observations: No senstisation observed in studies. No sensitizing properties from experience.
- Reading:
- other: long experience with human exposure to the substance
- Group:
- negative control
- Remarks on result:
- not measured/tested
- Remarks:
- No negative control exists due to a maximisation test with 25 volunteers long experience with human exposure to the substance
- Reading:
- other: long experience with human exposure to the substance
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Remarks:
- No positive control exists due to a maximisation test with 25 volunteers and a long experience with human exposure to the substance.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Taking into account the long experience with human exposure to the substance, and the absence of any reports on contact allergy in exposed persons, methyl acetate is not expected to exhibit skin sensitizing properties, especially since the substance is hydrolysed in contact with water by non-specific tissue esterases to methanol and acetic acid. For these substances a skin sensitisation potential is either absent (methanol, Fisher, 1986) or restricted to a few cases (acetic acid, Weil and Rogers, 1951).
- Executive summary:
The result meets the long experience from human exposure to humans.
Referenceopen allclose all
The study result meets the long experience from human exposure to humans. The test method of a maximization test is justified in this case.
"Total no. in group" refers to study by Kligman, only. This study is citied in EU-RAR, 2003.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a maximisation test with 25 volunteers no sensitisation was observed after exposure to 10% methyl acetate in petrolatum (Kligman, 1976). Taking into account the long experience with human exposure to the substance, and the absence of any reports on contact allergy in exposed persons, methyl acetate is not expected to exhibit skin sensitizing properties, especially since the substance is hydrolysed in contact with water by non-specific tissue esterases to methanol and acetic acid. For these substances a skin sensitisation potential is either absent (methanol, Fisher, 1986) or restricted to a few cases (acetic acid, Weil and Rogers, 1951).
From the overall data base and the long term experience with both methyl acetate and its hydrolysis products methanol and acetic acid it is concluded that methyl acetate has no sensitisation potential. The EU-RAR came to the same conclusion.
Literature
Kligman AM (1976). Report to RIFM (18.05.1976). Cited in: Opdyke (1979), Food Cosmet. Toxicol. 17, 859-861.
Fisher AA (1986). Contact Dermatitis. 3rd edition. Lea & Febiger, Philadelphia 1986, p. 853 and 886.
Weil AJ, Rogers HE (1951). Allergenic reactivity to simple aliphatic acids in man. J. Invest. Dermatol. 17, 227-231.
Migrated from Short description of key information:
Methyl acetate does not cause skin sensitisation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
From experience methyl acetate is not sensitising via the respiratory route. Studies on this endpoint are not available.
Justification for classification or non-classification
Methyl acetate is considered as non sensitising and does not trigger respective classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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