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Diss Factsheets
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EC number: 204-429-6 | CAS number: 120-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The SIDS dossier assigns a reliability of 1, valid without restrictions to this reference.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 2,4-dichlorophenol
- EC Number:
- 204-429-6
- EC Name:
- 2,4-dichlorophenol
- Cas Number:
- 120-83-2
- Molecular formula:
- C6H4Cl2O
- IUPAC Name:
- 2,4-dichlorophenol
- Details on test material:
- The purity of the test substance is reported to be 99.6%.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No additional details presented.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- Substance melted.
- Duration of exposure:
- Up to 9 days
- Doses:
- The dose levels were 200-300-1400 and 2000 mg/kg in males (5 animals/dose) and 200 and 2000 mg/kg in females (5 animals/dose).
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- The test substance was melted at 40 °C to obtain the liquid form to be tested. This was done in order to obtain a more pronounced toxic effect which can mimic accidents. The substance was applied under semi-occlusive patches during 24 h to the skin of Sprague-Dawley rats at a volume taking into consideration the density of the substance (d=1.38). The dose levels were 200-300-1400 and 2000 mg/kg in males (5 animals/dose) and 200 and 2000 mg/kg in females (5 animals/dose). The treated skin surface ranges between 2cm2 (200 mg/kg dose) and 30-35cm2 (2000 mg/kg dose).
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No preliminary study reported.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 780 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were 4/5 deaths at the highest dose level in both males and females. Death occurred within 6 days after application.
- Clinical signs:
- other: Slight decrease in motor activity was noted from 200 mg/kg and was no longer present 24 hours after application. Marked decrease in motor activity and respiratory impairment was observed from 300 mg/kg and 1400 mg/kg ; these signs were still present up to
- Other findings:
- At necropsy, presence of a liquid black in color in the urinary bladder of one male and one female at 2000 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 was determined to be 780 mg/kg/bw
- Executive summary:
The test substance was subjected to an acute dermal toxicity study according to OECD guideline 402. The study was performed to GLP. The LD50 was determined to be 780 mg/kg/bw. In addition, at all doses, marked to severe irritation resulting in skin necrosis was noted after removal of the patch, which was hardly reversible within 2 weeks.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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