Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-815-0 | CAS number: 16752-77-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- January 19, 2010- May 20, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EEC A.6
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 105
- Qualifier:
- according to guideline
- Guideline:
- other: OPPTS 830.7840
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Methomyl
DPX-X1179-599
Purity 99.6% - Key result
- Medium:
- acetone
- Solubility:
- > 790.24 - <= 798.84 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- ethyl acetate
- Solubility:
- > 194.61 - <= 205.21 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- methanol
- Solubility:
- > 1 000 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: dichloromethane
- Solubility:
- > 1 000 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: o-xylene
- Solubility:
- > 6.89 - <= 7.29 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: n-hexane
- Solubility:
- > 0.001 - <= 0.001 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- n-octanol
- Solubility:
- > 33.83 - <= 34.63 g/L
- Temp.:
- 20 °C
- Key result
- Medium:
- acetonitrile
- Solubility:
- > 1 000 mg/L
- Temp.:
- 20 °C
- Conclusions:
- The approximate solubility of DPX-X1179 was determined in acetone, ethyl acetate, methanol, dichloromethane, o-xylene, n-hexane, n-octanol and acetonitrile using the preliminary solubility test described in OECD Guideline 105. The preliminary test showed the solubility of DPX-X1179 in ethyl acetate, o-xylene, n-hexane and n-octanol to be <250 g/L, in methanol, dichloromethane and acetonitrile to be >1000 g/L and in acetone to be > 200 g/L at 20 ± 0.5°C. The actual solubility of DPX-X1179 was determined following the performance of the preliminary solubility test using either the shake flask method or the column elution method. The solubility of DPX-X1179 in the following solvents at 20 ± 0.5°C was determined to be: acetone: 794.54 ± 4.30 g/L; ethyl acetate: 199.91 ± 5.3 g/L; methanol: >1000 g/L; dichloromethane: >1000 g/L; o-xylene 7.09 ± 0.2 g/L; n-hexane: 0.00131 ± 1.3 x 10-4 g/L; n-octanol: 34.23 ± 0.4 g/L; acetonitrile: >1000 g/L.
- Executive summary:
The approximate solubility of DPX-X1179 was determined in acetone, ethyl acetate, methanol, dichloromethane, o-xylene, n-hexane, n-octanol and acetonitrile using the preliminary solubility test described in OECD Guideline 105. The preliminary test showed the solubility of DPX-X1179 in ethyl acetate, o-xylene, n-hexane and n-octanol to be <250 g/L, in methanol, dichloromethane and acetonitrile to be >1000 g/L and in acetone to be > 200 g/L at 20 ± 0.5°C. The actual solubility of DPX-X1179 was determined following the performance of the preliminary solubility test using either the shake flask method or the column elution method. The solubility of DPX-X1179 in the following solvents at 20 ± 0.5°C was determined to be: acetone: 794.54 ± 4.30 g/L; ethyl acetate: 199.91 ± 5.3 g/L; methanol: >1000 g/L; dichloromethane: >1000 g/L; o-xylene 7.09 ± 0.2 g/L; n-hexane: 0.00131 ± 1.3 x 10 -4 g/L; n-octanol: 34.23 ± 0.4 g/L; acetonitrile: >1000 g/L.
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- October 11, 2000- May 1, 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 105
- Version / remarks:
- 1995
- Qualifier:
- according to guideline
- Guideline:
- other: EEC A.6
- Version / remarks:
- 1992
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Methomyl
DPX-X1179-512
Purity 98.02% - Key result
- Medium:
- acetone
- Solubility:
- > 250 g/kg solvent
- Temp.:
- 20 °C
- Remarks on result:
- other: Definitive solubility value not determined
- Key result
- Medium:
- acetonitrile
- Solubility:
- > 250 g/kg solvent
- Temp.:
- 20 °C
- Remarks on result:
- other:
- Remarks:
- Definitive solubility value not determined
- Key result
- Medium:
- dimethylformamide
- Solubility:
- > 250 g/kg solvent
- Temp.:
- 20 °C
- Remarks on result:
- other: Definitive solubility value not determined
- Key result
- Medium:
- methanol
- Solubility:
- > 250 g/kg solvent
- Temp.:
- 20 °C
- Remarks on result:
- other: Definitive solubility value not determined
- Key result
- Medium:
- other: dichloromethane
- Solubility:
- > 250 g/kg solvent
- Temp.:
- 20 °C
- Remarks on result:
- other: Definitive solubility value not determined
- Key result
- Medium:
- ethyl acetate
- Solubility:
- ca. 77 400 mg/L
- Temp.:
- 20 °C
- Key result
- Medium:
- n-octanol
- Solubility:
- ca. 24 000 mg/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: n-heptane
- Solubility:
- ca. 97.1 mg/L
- Temp.:
- 20 °C
- Key result
- Medium:
- other: o-xylene
- Solubility:
- ca. 9 580 mg/L
- Temp.:
- 20 °C
- Conclusions:
- The solubility of methomyl was determined to be 77400 mg/L in ethyl acetate, 97.1 mg/L in n-heptane, 24000 mg/L in 1-octanol and 9580 mg/L in oxylene. Excess test substance was present in the test containers at each sample point for these four solvents. A minimum of three consecutive data points had concentrations within 5% of the average solubility for each solvent. The solubility of methomyl in acetone, acetonitrile, dichloromethane, dimethylformamide and methanol was determined to be greater than 250 grams of compound per kilogram of solvent. Definitive solubility values for these solvents were not determined; solubility was reported as > 250g/kg (European Union Commission Directive 91/414/EEC Annex IIA Point 2.7. as amended by Directive 94/37/EC, 22 July 1994).
- Executive summary:
This study determined the solubility of methomyl (DPX-X1179) in organic solvents as per OECD guideline 105 and EEC guideline A.6. The solubility of methomyl was determined to be 7.74 x 104 mg/L in ethyl acetate, 9.71 x 101 mg/L in n-heptane, 2.40 x 104 mg/L in 1 -octanol and 9.58 x 103 mg/L in o-xylene. Excess test substance was present in the test containers at each sample point for these four solvents. A minimum of three consecutive data points had concentrations within 5% of the average solubility for each solvent. The solubility of methomyl in acetone, acetonitrile, dichloromethane, dimethylformamide and methanol was determined to be greater than 250 grams of compound per kilogram of solvent. Definitive solubility values for these solvents were not determined; solubility was reported as > 250g/kg (European Union Commission Directive 91/414/EEC Annex IIA Point 2.7. as amended by Directive 94/37/EC, 22 July 1994).
Referenceopen allclose all
Description of key information
OECD 105; EEC A.6; OPPTS 830.7840
Key value for chemical safety assessment
Additional information
Solubility of test material at 20°C:
acetone: >250 g/kg solvent
acetonitrile: >250 g/kg solvent
dimethylformamide: >250 g/kg solvent
methanol: >250 g/kg solvent
dichloromethane: >250 g/kg solvent
ethylacetate: 7.74 x 104 g/L
n-heptane: 97.1 mg/L
1 -octanol: 2.40 x 104 mg/L
o-xylene: 9.58 x 103 g/L
n-hexane: 0.00131 x 10-4 g/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)