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EC number: 241-010-7 | CAS number: 16941-12-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 November 2002 - 20 December 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study conducted to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- No adjustment made for the specific gravity (2.07 g/ml) at the 25 mg/kg bw dose resulting in a 1.2% overdose which was considered to be within the experimental variation of oral dosing. Maximum 2% deviation from the minimum level for relative humidity.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Hexachloroplatinic acid
- EC Number:
- 241-010-7
- EC Name:
- Hexachloroplatinic acid
- Cas Number:
- 16941-12-1
- Molecular formula:
- Cl6Pt.2H
- IUPAC Name:
- platinum(4+) dihydrogen hexachloride
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Dihydrogen hexachloroplatinate (IV) solution
- Substance type: No data
- Physical state: liquid
- Analytical purity: 99.95%
- Impurities (identity and concentrations): not stated
- Purity test date: not stated
- Lot/batch No.: 4513936306
- Expiration date of the lot/batch: 12 September 2003
- Stability under test conditions: stable
- Storage condition of test material: room temperature in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar strain Crl:(Wl) BR (SPF quality)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland, Sulzfeld, Germany
- Age at study initiation: young animals (approx. 8 weeks old)
- Weight at study initiation: 191-287 g
- Fasting period before study: max 20 hr
- Housing: Macrolon cages containing purified sawdust
- Diet (e.g. ad libitum): standard pelleted lab animal diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/-3
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 70.8% by weight of the test substance
10 ml/kg bw for 25 mg/kg bw dose; 0.096 ml/kg bw (undiluted) for 200 mg/kg dose. - Doses:
- 25 and 200 mg/kg bw
- No. of animals per sex per dose:
- 3 females dosed at 200 mg/kg bw; 3 males and 3 females dosed at 25 mg/kg bw
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: twice daily (mortality/viability); days 1 (pre-administration), 8 and 15 (body weights); daily (clinical signs)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic examination
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 25 - < 200 mg/kg bw
- Mortality:
- 2 at 200 mg/kg bw and remaining animal in distress and sacrificed. No mortality occurred at 25 mg/kg bw.
- Clinical signs:
- other: 200 mg/kg bw slight hunched posture seen immediately post-dosing. By 4 h post-dose severe lethargy; severe clonic spasms and tremor (1 animal). Slight clinical signs of slow breathing, piloerection, watery dischange from eyes and ptosis developed by 2-4 h
- Gross pathology:
- 200 mg/kg bw: sStomach distended with gas in 2 animals. 25 mg/kg bw: no macroscopic findings.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 value of dihydrogen hexachloroplatinate was determined to be >25 mg/kg bw but <200 mg/kg bw in rats.
- Executive summary:
The acute toxicity of dihydrogen hexachloroplatinate was investigated in Wistar rats, in an OECD Test Guideline 423 study (acute toxic class method), conducted according to GLP. Initially, a group of three females received the test material via oral gavage at a dose of 200 mg/kg bw. Subsequently, rats (3/sex) were gavaged at a dose of 25 mg/kg bw and observed for 14 days.
Two animals treated at 200 mg/kg bw died, and the third was sacrificed in distress, at 4 hours post treatment. No mortality or signs of systemic toxicity were observed at the lower dose. The investigators stated that the oral LD50 was established to be in the range of 25-200 mg/kg bw.
Based on the results of this study, it is prudent to classify the test material for acute oral toxicity (category 2) according to EU CLP criteria (EC 1272/2008).
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