Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Biodegradation in water :
The biodegradability of the substance was calculated using seven different Biowin 1-7 models of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be not readily biodegradable.
Biodegradation in water and sediment :
Estimated half life of test chemical in water and sediment was 37.5 days (900 h) and 337.5 days (8100 h) respectively.
Biodegradation in soil : Biodegradation half-life of test substance in soil was estimated to be 75 days (1800 hrs).
Additional information
Biodegradation in water :
Predicted data of target chemical and supporting weight of evidence studies for it's structurally similar read across chemicals has been reviewed to determine the effect of the test chemical on biodegradation. The studies are as mentioned below:
First study includes estimation Programs Interface Suite (EPI suite, 2017) was run to predict the biodegradation potential of the test compound in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical was expected to be not readily biodegradable.
Second study includes biodegradation in water study was carried out for time period of 28 days by following the DOC-DIE AWAY TEST (EWG Guideline 79/831/EWG, Appendix V, Part C (updated edition dated July 1990), Method C.4-A. Test was carried out under aerobic condition. Benzoic acid, sodium salt was used as reference substance having > 98 % degradtion. Percentage degradation 0, 3 hours, and days 7, 14, 21, 27, 28 days were determined to be 0, 0, 47, 48, 49, 50, and 39%. Based on percentage degradation test chemical was considered as not readily biodegradable in water.
Third study includes biodegradation in water study was carried out for time period of 28 days under the aerobic condition, by following the method DOC-DIE AWAY TEST (EWG Guideline 79/831/EWG, Appendix V, Part C (updated edition dated July 1990), Method C.4-A. Activated sludge was used as test inoculum. Sodium benzoate, was used as reference substance of > 96% degradation.The DOC analysis was performed using two-point calibration in a carbon analyzer (Shimadzu). Percentage degradation of test chemical were determined to be 0, 31, 34, 33, 41, and 37% for 0, 7, 14, 21, 27, and 28 days, respectively. Thus, based on percentage degradation, test chemical was considered as not readily biodegradable in water.
The biodegradability of the substance was calculated using seven different Biowin 1-7 models of the BIOWIN v4.10 software. The results indicate that the test chemical is expected to be not readily biodegradable.
Based on above information test chemical was considered as not readily biodegradable in water.
Biodegradation in water and sediment :
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water for the test compound. If released in to the environment, 10.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low. Whearas half-life in sediment for the test compound in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment was less than 7%, indicates that test chemical was not persistent in sediment.
Biodegradation in soil :
The half-life period of test chemical in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 83.1 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
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