[No public or meaningful name is available]

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Remarks:

Read across data

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data was taken from secondary source

Data source

Reference

Reference Type:

other: Secondary source

Title:

SIDS Initial Assessment Report For SIAM 17

Author:

OECD-SIAM

Year:

2003

Bibliographic source:

OECD SIDS, SIAM, 2003

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Version / remarks:

1976

Principles of method if other than guideline:

Acute skin irritation in vivo study was carried out for the given test chemical using rabbit species of both sex for determing the erythma and edema score

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

3-aminopropyltriethoxysilane

EC Number:

213-048-4

EC Name:

3-aminopropyltriethoxysilane

Cas Number:

919-30-2

Molecular formula:

C9H23NO3Si

IUPAC Name:

3-AMINOPROPYLTRIETHOXYSILANE

Test material form:

liquid

Specific details on test material used for the study:

Not specified

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Dow Corning Corporation
- Age at study initiation:No data available
- Weight at study initiation: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum):No data available
- Acclimation period:No data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light):No data available

IN-LIFE DATES: From: To:No data available

Test system

Type of coverage:

not specified

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

Undilutated
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5ml

Duration of treatment / exposure:

4 hrs

Observation period:

14days

Number of animals:

4 animals

Details on study design:

Not specified

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

edema score

Basis:

mean

Remarks:

all 4 animals

Time point:

other: 24 hrs and 72 hrs

Score:

6.5

Max. score:

11

Reversibility:

not specified

Results 2

Irritation parameter:

erythema score

Basis:

mean

Remarks:

4 animals

Time point:

other: 24 hrs and 72 hrs

Score:

6.5

Max. score:

11

Reversibility:

not specified

Irritant / corrosive response data:

Moderate to severe erythema with edema was observed on all animals after 24 hours exposure to the test material.After 72 hours, irritation became more pronounced on the abraded skin, leading to the formation of eschars

Other effects:

Not specified

Applicant's summary and conclusion

Interpretation of results:

Category 1 (corrosive) based on GHS criteria

Conclusions:

An unfailing study, like OECD 404, found that test material was corrosive when in contact for 4 h in rabbits, the erthyma and edema score was found to be 6.5

Executive summary:

An unfailing study, like OECD "Acute Dermal Irritation/Corrosion" was performed for the RA chemical 3-aminopropyltriethoxysilane(CAS 919-30-2)using rabbits. The RA chemical was applied to all the animals at a dose of 0.5ml and observed for 72  hrs. After 24 hrs applications of a test sample to rabbit skin resulted in Moderate to severe erythema with edema observed on all animals. After 72 hours, irritation became more pronounced on the abraded skin, leading to the formation of eschars. The Primary Irritation Index was calculated to be 6.5. Hence the test material may classified as  irritant to the skin of rabbits