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EC number: 915-730-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- BCF (aquatic species):
- 391 L/kg ww
Additional information
Bioconcentration and metabolism of OTNE in Lepomis macrochirus was investigated according to international guidelines (OPPTS 850.1730 / OECD Guideline 305) under GLP. Validity criteria for the test were met. OTNE was extensively metabolised by the fish, therefore the BCF was determined both by the kinetic approach (k1/k2) and by the steady state approach (Cf/Cw). There is no significant difference between these BCFs, nor between the BCFs for the high and low dose treatment. In the steady state approach, the BCF was also calculated with the measured OTNE concentration in the premix chamber.
The results show that the BCF is 603 and 593 in the low and high treatment. Based on total radioactivity in fish and the premix chamber containing no metabolites, the corresponding BCF value is 747 and 736. This indicates that part of the extracted radioactivity in the fish is to be attributed to metabolites. The DT50 was found to be 1.2 day.
OTNE was extensively metabolised by the fish. A total of 6 components including OTNE were detected in fish fillet. In fish viscera, OTNE (approximately 50% of TRR) as well as two major polar metabolites (comprising 30% to 35% TRR) were observed. In viscera approximately 7-10 components were detected. Most of the metabolites present in the viscera samples were also present in the water in the aquaria, indicating that these were actively excreted from the fish into water.
The average lipid content of the fish was 7.7%. For subsequent calculations the empirical BCF of 603 was converted to a standard fish with a lipid content of 5%. Thus, a BCF of 603/7.7 * 5 = 391 is used for the further evaluations.
Mass balance calculations based on the study report indicate that 80 -93% of the residual radio-activity in the water can be explained by the presence of excreted metabolites.
Mass balance (further calculations based on study report):
Most of the metabolites present in the viscera samples were also present in the water in the aquaria, indicating that these were actively excreted from the fish into water (Madsen et al 1999). Analysis of the water suggested that the metabolism of OTNE in fish tissues was relatively rapid. OTNE levels in water at steady state were less than 40%, in spite of the high daily turnover rate of 7.3 – 8 times for the test solution. This implies that around 60% of the test material can be attributed to metabolites.
Mass balances were calculated based on the loss of radioactivity k2multiplied with the plateau concentration TRR at day 21 for the whole fish. Multiplication of this ‘loss’ by the average fish-to-water loading rate (0.93 g/l day-1) gives the nominal concentration of ‘lost’ radioactivity in water leaving the system: 0.65 μg/l in the low treatment and 5.60 μg/l in the high treatment. Comparing these concentrations to the average measured concentrations of metabolites in water (day 14 and 21): 0.7 μg/l for the low treatment and 7.02 μg/l for the high treatment, shows that 93% and 80% of the totally applied radioactivity can be accounted for.
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