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Diss Factsheets
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EC number: 915-730-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 March 1980 - 1 April 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed similar to the OECD TG 402 "Acute Dermal Toxicity", 1987, but was not performed under GLP. Report is well documented, and the design is considered scientifically accepted.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 8 male and 8 female rat, one dose tested
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction Mass of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one and 1-(1,2,3,4,6,7,8,8a-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one and 1-(1,2,3,5,6,7,8,8a-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one
- EC Number:
- 915-730-3
- Molecular formula:
- C16H26O
- IUPAC Name:
- Reaction Mass of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one and 1-(1,2,3,4,6,7,8,8a-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one and 1-(1,2,3,5,6,7,8,8a-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one
- Reference substance name:
- 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one
- EC Number:
- 259-174-3
- EC Name:
- 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one
- Cas Number:
- 54464-57-2
- Molecular formula:
- C16H26O
- IUPAC Name:
- 1-(2,3,8,8-tetramethyl-1,2,3,4,5,6,7,8-octahydronaphthalen-2-yl)ethanone
- Reference substance name:
- 1-(1,2,3,5,6,7,8,8a-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one
- EC Number:
- 268-978-3
- EC Name:
- 1-(1,2,3,5,6,7,8,8a-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one
- Cas Number:
- 68155-66-8
- Molecular formula:
- C16H26O
- IUPAC Name:
- 1-(2,3,8,8-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalen-2-yl)ethanone
- Reference substance name:
- 1-(1,2,3,4,6,7,8,8a-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one
- EC Number:
- 268-979-9
- EC Name:
- 1-(1,2,3,4,6,7,8,8a-octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethan-1-one
- Cas Number:
- 68155-67-9
- Molecular formula:
- C16H26O
- IUPAC Name:
- 1-(2,3,8,8-tetramethyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-2-yl)ethanone
- Test material form:
- liquid
1
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Labs (Wilmington, Mass., USA)
- Age at study initiation: no data
- Weight at study initiation: 180 to 280 grams
- Housing: singly in wire cages under standard laboratory conditions meeting the standards described in the 'Guide for the Care and Use of Laboratory Animals' (DHEW Publication No. (NIH) 78-23 Revised 1978).
- Diet: Purina Rodent Laboratory Chow 5001 ad libitum
- Water: ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- other: SDA39C (alcoholic solution)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: area bounded by the nape of the neck, the mid dorsum between pectoral and pelvic girdles and the lateral aspects of the scapulae (the backs of the rats were clipped from the scapular region to the hips a day prior to treatment)
- % coverage: less than 30% of the body surface
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiping with a clean cloth
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml/100 g bw
- Concentration (if solution): 5000 mg/kg bw
- Constant volume or concentration used: yes, constant concentration - Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 8 males and 8 females
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: mortality and pharmacotoxic signs: at 1, 3, 5 and 24 hours following dosing and twice daily (once daily on weekends) for the remainder of the 14 day observation period. Weighing: Pre-dose and Day 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, other: necropsy-tissues examined: lungs, heart, liver, spleen, kidney, adrenals, bladder, stomach, intestines. Other tissues examined grossly: the external carcass (fur, skin and orifices), peritoneal and pleural mucosa, internal mesentery.
Results and discussion
- Preliminary study:
- In a preliminary range finding assay in which two rats (one of each sex) were treated at 5000 mg/kg bw., there were no deaths during the 72 hour observation period.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: No mortality noted at this dose level.
- Mortality:
- No mortality was seen in the 8 males and 8 females dosed with the test article.
- Clinical signs:
- other: There were no clinical signs of toxicity in any animal dosed at 5000 mg/kg bw. All the animals appeared normal in health and behavior throughout the 14 day observation period.
- Gross pathology:
- There were no signs indicative of toxicity in any of the rats necropsied at term. No visible lesions in the tissues examined.
Applicant's summary and conclusion
- Interpretation of results:
- other: criteria are not met
- Remarks:
- according to EU CLP (1272/2008 and its amendments)
- Conclusions:
- This study found no effects that related to acute dermal toxicity in rats after administrating a single dose of 5000 mg/kg bw. The LD50 was in excess of 5000 mg/kg.
- Executive summary:
The dermal acute toxicity of the substance, a yellow liquid, was examined according to a similar to OECD TG 402, 1987, protocol. First a preliminary study was performed with x males and females. In the final study eight male and eight female albino rats (Sprague-Dawley CD strain) were used. The animals weighing between 180 and 280 grams, were clipped on the day prior to dosing and the test substance, prepared in the diluent supplied, was applied onto the skin at 5000 mg/kg bw. The volume of the solution administered was 0.5 ml/100 g bw.
In the preliminary study no mortality occurred in 72h. In the main study none of the test animals showed any clinical signs indicative of systemic toxicity. All of the animals remained healthy throughout the study and gained weight in a normal manner. At necropsy performed on the survivors at term, none of the animals had any signs indicative of systemic toxicity. The dermal LD50 was greater than 5000 mg/kg bw.
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